TY - JOUR
T1 - Chitosan Hydrogel in combination with Nerolidol for healing wounds
AU - Ferreira, Maria Onaira Gonçalves
AU - Leite, Layara Lorrana Ribeiro
AU - Lima, Idglan Sá de
AU - Barreto, Humberto Medeiros
AU - Nunes, Lívio César Cunha
AU - Ribeiro, Alessandra Braga
AU - Osajima, Josy Anteveli
AU - Filho, Edson Cavalcanti da Silva
N1 - Funding Information:
Maria Onaira Gonçalves Ferreira acknowledges CAPES Foundation (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), Ministry of Education of Brazil, the financial support for the grant. Alessandra Braga Ribeiro acknowledges CNPq for the DCR-grant (n.301267/2015-4).
Publisher Copyright:
© 2016 Elsevier Ltd
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/11/5
Y1 - 2016/11/5
N2 - Chitosan is a natural polymer with antibacterial property, that is biodegradable, extremely abundant and non-toxic. This study aimed to develop and characterize chitosan hydrogels in combination with nerolidol, in order to optimize the antimicrobial and healing properties. The hydrogels were prepared using a reaction of the chitosan with acetic acid solution, followed by the addition of 2 or 4% of the nerolidol. Using thermogravimetry, differential scanning calorimetry and infrared spectroscopy, the incorporation of nerolidol in the hydrogel was confirmed. Direct contact tests using hydrogels and Staphylococcus aureus showed a synergistic effect in the materials, enabling total inhibition of bacterial growth. The hydrogel containing 2% nerolidol showed excellent healing effects. The beginning of re-epithelialization and reorganization of collagen was already observed on the 7th day of treatment. The material created proofed to be promising as a healing and antibacterial agent.
AB - Chitosan is a natural polymer with antibacterial property, that is biodegradable, extremely abundant and non-toxic. This study aimed to develop and characterize chitosan hydrogels in combination with nerolidol, in order to optimize the antimicrobial and healing properties. The hydrogels were prepared using a reaction of the chitosan with acetic acid solution, followed by the addition of 2 or 4% of the nerolidol. Using thermogravimetry, differential scanning calorimetry and infrared spectroscopy, the incorporation of nerolidol in the hydrogel was confirmed. Direct contact tests using hydrogels and Staphylococcus aureus showed a synergistic effect in the materials, enabling total inhibition of bacterial growth. The hydrogel containing 2% nerolidol showed excellent healing effects. The beginning of re-epithelialization and reorganization of collagen was already observed on the 7th day of treatment. The material created proofed to be promising as a healing and antibacterial agent.
KW - Bactericide
KW - Cicatrization
KW - Dressing
KW - Drug
KW - Gel
KW - Healing
KW - Injury
UR - https://www.scopus.com/pages/publications/84978532197
U2 - 10.1016/j.carbpol.2016.07.037
DO - 10.1016/j.carbpol.2016.07.037
M3 - Article
C2 - 27516288
AN - SCOPUS:84978532197
SN - 0144-8617
VL - 152
SP - 409
EP - 418
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
ER -