Clinical features related to severity and mortality among COVID-19 patients in a pre-vaccine period in Luanda, Angola

Cruz S. Sebastião, Adis Cogle, Alice D’Alva Teixeira, Ana Micolo Cândido, Chissengo Tchoni, Maria João Amorim, N’gueza Loureiro, Paolo Parimbelli, Carlos Penha-Gonçalves, Jocelyne Demengeot, Euclides Sacomboio, Manuela Mendes, Margarete Arrais, Joana Morais, Jocelyne Neto de Vasconcelos, Miguel Brito*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

9 Transferências (Pure)

Resumo

Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola. Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample t-tests and Chi-square tests. The results were deemed significant when p < 0.05. Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05). Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.

Idioma originalEnglish
Número do artigo338
Número de páginas11
RevistaTropical Medicine and Infectious Disease
Volume7
Número de emissão11
DOIs
Estado da publicaçãoPublicado - 29 out 2022

Impressão digital

Mergulhe nos tópicos de investigação de “Clinical features related to severity and mortality among COVID-19 patients in a pre-vaccine period in Luanda, Angola“. Em conjunto formam uma impressão digital única.

Citação