TY - JOUR
T1 - Clinical features related to severity and mortality among COVID-19 patients in a pre-vaccine period in Luanda, Angola
AU - Sebastião, Cruz S.
AU - Cogle, Adis
AU - Teixeira, Alice D’Alva
AU - Cândido, Ana Micolo
AU - Tchoni, Chissengo
AU - Amorim, Maria João
AU - Loureiro, N’gueza
AU - Parimbelli, Paolo
AU - Penha-Gonçalves, Carlos
AU - Demengeot, Jocelyne
AU - Sacomboio, Euclides
AU - Mendes, Manuela
AU - Arrais, Margarete
AU - Morais, Joana
AU - Vasconcelos, Jocelyne Neto de
AU - Brito, Miguel
N1 - Funding Information:
Financial support was provided by the Fundação Calouste Gulbenkian (FCG)/Camões, IP agreement nr. 2208700707/22.10.202, and Science and Technology Development Project Funding agreement 11/MESCTI/PDCT/2020 for the action entitled Building COVID-19 Response Capacity in Angola.
Funding Information:
The authors are grateful for the participation of all Angolan COVID-19 patients enrolled in the study. We also wish to express our gratitude to the Fundação Calouste Gulbenkian (FCG) and Camões, IP, for financial assistance. Gratitude also goes to the CISA, INIS, Hospital Militar Principal, Clínica Girassol, and Lucrécia Paim Maternity, for institutional backing. We also want to recognize Anabela Mateus, Welwitschia Dias, Luzia Quipungo, Luísa Dachala, Bruno Cardoso, Celestina Gaston, Domingos Biete Alfredo, Janete António, Manuela Galangue, and Francisco Manuel for laboratory support or patient recruitment; Zinga David and António Mateus to provide administrative support; Vera Mendes and Joana Sebastião for logistical assistance.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/10/29
Y1 - 2022/10/29
N2 - Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola. Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample t-tests and Chi-square tests. The results were deemed significant when p < 0.05. Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05). Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.
AB - Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola. Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample t-tests and Chi-square tests. The results were deemed significant when p < 0.05. Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05). Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.
KW - Angola
KW - Clinical features
KW - COVID-19
KW - Luanda
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85141748662&partnerID=8YFLogxK
U2 - 10.3390/tropicalmed7110338
DO - 10.3390/tropicalmed7110338
M3 - Article
C2 - 36355881
AN - SCOPUS:85141748662
VL - 7
JO - Tropical Medicine and Infectious Disease
JF - Tropical Medicine and Infectious Disease
SN - 2414-6366
IS - 11
M1 - 338
ER -