TY - JOUR
T1 - Comparative differences in the atherosclerotic disease burden between the epicardial coronary arteries
T2 - Quantitative plaque analysis on coronary computed tomography angiography
AU - PARADIGM investigators
AU - Bax, A. Maxim
AU - Van Rosendael, Alexander R.
AU - Ma, Xiaoyue
AU - Van Den Hoogen, Inge J.
AU - Gianni, Umberto
AU - Tantawy, Sara W.
AU - Hollenberg, Emma J.
AU - Andreini, Daniele
AU - Al-Mallah, Mouaz H.
AU - Budoff, Matthew J.
AU - Cademartiri, Filippo
AU - Chinnaiyan, Kavitha
AU - Choi, Jung Hyun
AU - Conte, Edoardo
AU - Marques, Hugo
AU - Gonçalves, Pedro de Araújo
AU - Gottlieb, Ilan
AU - Hadamitzky, Martin
AU - Leipsic, Jonathon A.
AU - Maffei, Erica
AU - Pontone, Gianluca
AU - Shin, Sanghoon
AU - Kim, Yong Jin
AU - Lee, Byoung Kwon
AU - Chun, Eun Ju
AU - Sung, Ji Min
AU - Lee, Sang Eun
AU - Virmani, Renu
AU - Samady, Habib
AU - Stone, Peter H.
AU - Berman, Daniel S.
AU - Min, James K.
AU - Narula, Jagat
AU - Lin, Fay Y.
AU - Chang, Hyuk Jae
AU - Shaw, Leslee J.
N1 - Funding Information:
This work was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation funded by the Ministry of Science and Information and Communications Technology of Korea (Grant no. 2012027176). Additional funding was provided by a gift from the Dalio Foundation (New York, NY) and the MichaelWolk Foundation (New York, NY).
Publisher Copyright:
© 2020 Published on behalf of the European Society of Cardiology. All rights reserved.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Aims: Anatomic series commonly report the extent and severity of coronary artery disease (CAD), regardless of location. The aim of this study was to evaluate differences in atherosclerotic plaque burden and composition across the major epicardial coronary arteries. Methods and results: A total of 1271 patients (age 60 ± 9 years; 57% men) with suspected CAD prospectively underwent coronary computed tomography angiography (CCTA). Atherosclerotic plaque volume was quantified with categorization by composition (necrotic core, fibrofatty, fibrous, and calcified) based on Hounsfield Unit density. Per-vessel measures were compared using generalized estimating equation models. On CCTA, total plaque volume was lowest in the LCx (10.0 ± 29.4 mm3), followed by the RCA (32.8 ± 82.7 mm3; P < 0.001), and LAD (58.6 ± 83.3 mm3; P < 0.001), even when correcting for vessel length or volume. The prevalence of ≥2 high-risk plaque features, such as positive remodelling or spotty calcification, occurred less in the LCx (3.8%) when compared with the LAD (21.4%) or RCA (10.9%, P < 0.001). In the LCx, the most stenotic lesion was categorized as largely calcified more often than in the RCA and LAD (55.3% vs. 39.4% vs. 32.7%; P < 0.001). Median diameter stenosis was also lowest in the LCx (16.2%) and highest in the LAD (21.3%; P < 0.001) and located more distal along the LCx when compared with the RCA and LAD (P < 0.001). Conclusion: Atherosclerotic plaque, irrespective of vessel volume, varied across the epicardial coronary arteries; with a significantly lower burden and different compositions in the LCx when compared with the LAD and RCA. These volumetric and compositional findings support a diverse milieu for atherosclerotic plaque development and may contribute to a varied acute coronary risk between the major epicardial coronary arteries.
AB - Aims: Anatomic series commonly report the extent and severity of coronary artery disease (CAD), regardless of location. The aim of this study was to evaluate differences in atherosclerotic plaque burden and composition across the major epicardial coronary arteries. Methods and results: A total of 1271 patients (age 60 ± 9 years; 57% men) with suspected CAD prospectively underwent coronary computed tomography angiography (CCTA). Atherosclerotic plaque volume was quantified with categorization by composition (necrotic core, fibrofatty, fibrous, and calcified) based on Hounsfield Unit density. Per-vessel measures were compared using generalized estimating equation models. On CCTA, total plaque volume was lowest in the LCx (10.0 ± 29.4 mm3), followed by the RCA (32.8 ± 82.7 mm3; P < 0.001), and LAD (58.6 ± 83.3 mm3; P < 0.001), even when correcting for vessel length or volume. The prevalence of ≥2 high-risk plaque features, such as positive remodelling or spotty calcification, occurred less in the LCx (3.8%) when compared with the LAD (21.4%) or RCA (10.9%, P < 0.001). In the LCx, the most stenotic lesion was categorized as largely calcified more often than in the RCA and LAD (55.3% vs. 39.4% vs. 32.7%; P < 0.001). Median diameter stenosis was also lowest in the LCx (16.2%) and highest in the LAD (21.3%; P < 0.001) and located more distal along the LCx when compared with the RCA and LAD (P < 0.001). Conclusion: Atherosclerotic plaque, irrespective of vessel volume, varied across the epicardial coronary arteries; with a significantly lower burden and different compositions in the LCx when compared with the LAD and RCA. These volumetric and compositional findings support a diverse milieu for atherosclerotic plaque development and may contribute to a varied acute coronary risk between the major epicardial coronary arteries.
KW - Coronary artery disease
KW - Coronary artery plaque composition
KW - Coronary computed tomography angiography
UR - http://www.scopus.com/inward/record.url?scp=85102222488&partnerID=8YFLogxK
U2 - 10.1093/ehjci/jeaa275
DO - 10.1093/ehjci/jeaa275
M3 - Article
C2 - 33215192
AN - SCOPUS:85102222488
SN - 2047-2404
VL - 22
SP - 322
EP - 330
JO - European Heart Journal. Cardiovascular Imaging
JF - European Heart Journal. Cardiovascular Imaging
IS - 3
ER -