Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia

GENFI Consortium, Carolina Maruta

Resultado de pesquisarevisão de pares

16 Citações (Scopus)

Resumo

The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages.

Idioma originalEnglish
Páginas (de-até)1408-1423
Número de páginas16
RevistaAlzheimer's and Dementia
Volume18
Número de emissão7
DOIs
Estado da publicaçãoPublicado - 1 jul. 2022
Publicado externamenteSim

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