The present research is a quantitative study that aims at validating the content result of the Nursing Outcomes Classification (NOC) “Consequences of substance addiction “. NOC research teams and Fehring model recommendations were observed. Results presented 16 indicators; 12 were added according to literature; four were discarded. Final questionnaire proposed 24 indicators; 10 with values > 0.80 (primary) and 14 with values > 0.50 and < 0.80 (secondary). Experts agreed upon indicators added: eight primary and four secondary. Four NOC original indicators were excluded (< 0.50) and two were classified as primary. Current research includes a content-validated multidimensional view of the drug abuse phenomenon; it informs nurses about physical, psychological, social and spiritual interventions. The study precedes clinical validation. Researchers recommend it to be used in a broad sample of poly drug users, in order to obtain a new tool that contributes to a more systematic care and meets those specific health needs.