Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region

Mário Ribeiro Da Silva, Ruth Maria Dias Ferreira Vinagre, Adenielson Vilar E Silva, Claudia Suellen Ferro De Oliveira, Kemper Nunes Do Santos, Renata Aparecida Andrade Da Costa, Amanda Alves Fecury, Tereza Cristina De Oliveira Corvelo, Juarez Antônio Simões Quaresma, Luisa Caricio Martins*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

6 Citações (Scopus)

Resumo

Introduction: This study compares virulence markers of Helicobacter pylori isolated from patients in 2 cities in the Brazilian Amazon. Methods: The study analyzed 168 patients with chronic gastritis from Belém and 151 from Bragançã, State of Para, Brazil. Levels of bacterial DNA associated with cagA and vacA alleles were checked by PCR, and hematoxylin-eosin staining was used for histologic diagnosis. Results: In Bragançã 87% of patients were genotype slml cogA-positive (slml cagA+), compared with 76% in Belém. In samples from patients in both cities, there was an association between slml cagA+ strains and gastric mucosal damage. Conclusions: Both cities have a high frequency of slml cagA+ strains of H. pylori.

Idioma originalEnglish
Páginas (de-até)358-361
Número de páginas4
RevistaRevista da Sociedade Brasileira de Medicina Tropical
Volume46
Número de emissão3
DOIs
Estado da publicaçãoPublicado - mai. 2013
Publicado externamenteSim

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