Distribution of distances between symmetric words in the human genome: analysis of regular peaks

Carlos A. C. Bastos*, Vera Afreixo, João M. O. S. Rodrigues, Armando J. Pinho, Raquel M. Silva

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

1 Citação (Scopus)

Resumo

Finding DNA sites with high potential for the formation of hairpin/cruciform structures is an important task. Previous works studied the distances between adjacent reversed complement words (symmetric word pairs) and also for non-adjacent words. It was observed that for some words a few distances were favoured (peaks) and that in some distributions there was strong peak regularity. The present work extends previous studies, by improving the detection and characterization of peak regularities in the symmetric word pairs distance distributions of the human genome. This work also analyzes the location of the sequences that originate the observed strong peak periodicity in the distance distribution. The results obtained in this work may indicate genomic sites with potential for the formation of hairpin/cruciform structures.
Idioma originalEnglish
Páginas (de-até)367-372
Número de páginas6
RevistaInterdisciplinary Sciences: Computational Life Sciences
Volume11
Número de emissão3
DOIs
Estado da publicaçãoPublished - 1 set 2019
Publicado externamenteSim

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