Drug delivery strategies and biomedical significance of hydrogels: translational considerations

Neha Raina, Rakesh Pahwa, Jaydeep Bhattacharya, Alok K. Paul, Veeranoot Nissapatorn*, Maria de Lourdes Pereira, Sonia M. R. Oliveira, Karma G. Dolma, Mohammed Rahmatullah, Polrat Wilairatana*, Madhu Gupta*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

23 Citações (Scopus)
2 Transferências (Pure)

Resumo

Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for several purposes in the biomedical sector using versatile polymers of synthetic and natural origin. This review focuses on functional polymeric materials for the fabrication of hydrogels, evaluation of different parameters of biocompatibility and stability, and their application as carriers for drugs delivery, tissue engineering and other therapeutic purposes. The outcome of various studies on the use of hydrogels in different segments and how they have been appropriately altered in numerous ways to attain the desired targeted delivery of therapeutic agents is summarized. Patents and clinical trials conducted on hydrogel-based products, along with scale-up translation, are also mentioned in detail. Finally, the potential of the hydrogel in the biomedical sector is discussed, along with its further possibilities for improvement for the development of sophisticated smart hydrogels with pivotal biomedical functions.
Idioma originalEnglish
Número do artigo574
Páginas (de-até)1-31
Número de páginas31
RevistaPharmaceutics
Volume14
Número de emissão3
DOIs
Estado da publicaçãoPublicado - mar. 2022
Publicado externamenteSim

Impressão digital

Mergulhe nos tópicos de investigação de “Drug delivery strategies and biomedical significance of hydrogels: translational considerations“. Em conjunto formam uma impressão digital única.

Citação