Edible films as oral delivery systems for xanthines extracted from medicinal plants: an experimental design approach

Pedro M. Castro, Ana Oliveira, Pedro Fonte, Ana Raquel Madureira, Bruno Sarmento, Manuela Pintado*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

3 Transferências (Pure)

Resumo

Two formulations of edible films intended for oral delivery of therapeutic xanthines were developed, following an experimental design approach. Gelatin type A and sodium carboxymethylcellulose were used as polymeric matrices with different physico-chemical nature. Caffeine, a well-known methylxhanthine, was used as model bioactive molecule, representing overall xanthines (e.g. caffeine, theophylline, theobromine) extracted from medicinal plants. Fourier-transform infrared spectroscopy (FTIR) analysis was performed to outwit the formation of covalent bonds between caffeine and the matrix of edible films. Scanning electron microscopy (SEM) was performed to assess if caffeine was homogeneously dispersed on the matrix of edible films. Simulation of gastrointestinal tract and ex vivo permeability studies across intestinal mucosa were performed to predict the delivery profile of caffeine from developed formulations of edible films. Gelatin type A-based edible films offered a slow release of caffeine whereas sodium carboxymethylcellulose-based edible films promote an immediate release of caffeine.
Idioma originalEnglish
Páginas32-32
Número de páginas1
Estado da publicaçãoPublicado - jun. 2016
EventoInternational Conference: Aromatic and Medicinal Herbs in Food - Caro Hotel, Eminescu Conference room, Bucharest
Duração: 15 jun. 201616 jun. 2016

Conferência

ConferênciaInternational Conference
País/TerritórioRomania
CidadeBucharest
Período15/06/1616/06/16

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