Effect of carbonate-apatite on bone repair in non-critical size defect of rat calvaria

H. Valiense*, G. V. O. Fernandes, B. Moura, J. Calasans-Maia, A. Alves, A. Rossi, J. M. Granjeiro, M. Calasans-Maia

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

4 Citações (Scopus)

Resumo

The objective of this study was to investigate the bone repair of carbonate apatite (cHA) in comparison to hydroxyapatite (HA, control group), on osseous repair of non-critical size defect in rat calvaria. Spheres (400<ø> 500μm) of both materials were synthesized under 37°C (cHA) and 90°C (HA) and were not sintered. Fifteen rats Wistar were submitted to general anesthesia and two perforations (4mm each) were made, one in each parietal bone, for implantation of cHA (left side) and HA spheres (right side). After 1, 3 and 6 weeks, five animals of each group were killed and the two fragments with the biomaterial were collected from the calvaria. The bone blocks with biomaterial were demineralized and 5μm thick semi-serial sections were done for histological analysis. The experimental group of 6 weeks did not show the presence of spheres of both biomaterials and few spheres were observed after 1 and 3 weeks. Histological analysis showed the connective tissue repairing the surgical defect after 1 week and newly formed bone after 3 weeks of surgery. Thus, we concluded both materials are biocompatible, promote osteoconduction and in all studied periods the biomaterials showed to be resorbable.
Idioma originalEnglish
Título da publicação do anfitriãoBioceramics 23
EditoraTrans Tech Publications Ltd
Páginas258-262
Número de páginas5
ISBN (impresso)9783037852552
DOIs
Estado da publicaçãoPublicado - 2012
Publicado externamenteSim
Evento23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011 - Istanbul
Duração: 6 nov 20119 nov 2011

Série de publicação

NomeKey Engineering Materials
Volume493-494
ISSN (impresso)1013-9826
ISSN (eletrónico)1662-9795

Conferência

Conferência23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011
País/TerritórioTurkey
CidadeIstanbul
Período6/11/119/11/11

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