Effect of hydroxyapatite and zinc-containing hydroxyapatite on osseous repair of critical size defect in the rat calvaria

M. Calasans-Maia*, G. V. O. Fernandes, A. Rossi, E. P. Dias, G. D. S. Almeida, F. F. Mitri, J. M. Granjeiro

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

14 Citações (Scopus)

Resumo

Hydroxyapatite (HA), widely used as bone graft, can be modified by the incorporation of bivalent cations (Mg 2- and Zn2+) and its gradual release could favor the bone repair. The purpose of this research was to evaluate the effect of the HA and zinc-containing hydroxyapatite (Zn-HA) in the bone repair in rat calvaria in comparison to autogenous bone. Critical size defect in the calvaria was filled with the graft material and the samples were harvested at the 30, 90 and 180 days. The light microcopy observations showed the biocompatibility of the graft materials. In the Zn-HA group the area of neoformed bone was larger than in the HA group, but smaller than in the autograft. A fibrous connective tissue was more evident around HA granules. It could be conclude that the presence of zinc ions in HA crystal accelerated the osteogenesis and increased the area of newly formed bone in relation to HA.
Idioma originalEnglish
Páginas1273-1276
Número de páginas4
DOIs
Estado da publicaçãoPublicado - 2008
Publicado externamenteSim
Evento20th International Symposium on Ceramics in Medicine - Nantes
Duração: 24 out 200726 out 2007
Número de conferência: 20

Conferência

Conferência20th International Symposium on Ceramics in Medicine
País/TerritórioFrance
CidadeNantes
Período24/10/0726/10/07

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