Ethylene oxide sterilization of medical devices: a review

Gisela C.C. Mendes, Teresa R.S. Brandão, Cristina L.M. Silva*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

215 Citações (Scopus)
3 Transferências (Pure)


Ethylene oxide (EO) is a well-known sterilizing agent. However, only recently has its use significantly emerged, based on its range of applications in the field of new medical device development and sterilization. This paper describes the progress in terms of EO sterilization and concludes that it remains a promising field to explore and develop. The EO action mechanism and toxicity are analyzed, and a critical analysis is made on how it is possible to use EO sterilization for medical devices advantageously, with emphasis on cycle design and validation. One huge challenge is related with the development of mathematical models to integrate lethality to allow a continuous increase of process flexibility, without compromising its safety. The scientific community should also focus on other important issues, such as EO diffusion in different substrates, taking into account different environmental conditions both for sterilization and aeration.

Idioma originalEnglish
Páginas (de-até)574-581
Número de páginas8
RevistaAmerican Journal of Infection Control
Número de emissão9
Estado da publicaçãoPublished - nov 2007

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