Fatal hepatitis B reactivation treated with entecavir in an isolated anti-HBs positive lymphoma patient: A case report and literature review

Rosa Ferreira*, Joana Carvalheiro, Joana Torres, Alexandra Fernandes, Sílvia Giestas, Sofia Mendes, Cláudia Agostinho, Mário J. Campos

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

17 Citações (Scopus)

Resumo

Hepatitis B virus (HBV) reactivation is a well-recognized complication that occurs in lymphoma patients who undergo chemotherapy. Only very few cases of HBV reactivation in patients with isolated antibody against hepatitis B surface antigen (anti-HBs) have been reported. We present a case of a 78-year-old woman diagnosed with diffuse large B cell non-Hodgkin′s lymphoma who only displayed a positive anti-HBs, as the single possible marker of occult HBV infection, before starting therapy. She was treated with several chemotherapeutic regimens (including rituximab) for disease relapses during 3 years. Forty days after the last cycle of chemotherapy, she presented with jaundice, markedly elevated serum aminotransferase levels, and coagulopathy. HBV serology showed positivity for HBsAg, anti-HBc and anti-HBs. HBV DNA was positive. Antiviral treatment with entecavir was promptly initiated, but the patient died from liver failure. A review of the literature of HBV reactivation in patients with detectable anti-HBs levels is discussed.

Idioma originalEnglish
Páginas (de-até)277-281
Número de páginas5
RevistaSaudi Journal of Gastroenterology
Volume18
Número de emissão4
DOIs
Estado da publicaçãoPublicado - jul. 2012
Publicado externamenteSim

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