Genomic and epidemiological surveillance of Zika virus in the Amazon region

Marta Giovanetti, Nuno Rodrigues Faria*, José Lourenço, Jaqueline Goes de Jesus, Joilson Xavier, Ingra Morales Claro, Moritz U.G. Kraemer, Vagner Fonseca, Simon Dellicour, Julien Thézé, Flavia da Silva Salles, Tiago Gräf, Paola Paz Silveira, Valdinete Alves do Nascimento, Victor Costa de Souza, Felipe Campos de Melo Iani, Emerson Augusto Castilho-Martins, Laura Nogueira Cruz, Gabriel Wallau, Allison FabriFlávia Levy, Joshua Quick, Vasco de Azevedo, Renato Santana Aguiar, Tulio de Oliveira, Camila Bôtto de Menezes, Marcia da Costa Castilho, Tirza Matos Terra, Marineide Souza da Silva, Ana Maria Bispo de Filippis, André Luiz de Abreu, Wanderson Kleber Oliveira, Julio Croda, Carlos F. Campelo de Albuquerque, Marcio R.T. Nunes, Ester Cerdeira Sabino, Nicholas Loman, Felipe Gomes Naveca, Oliver G. Pybus, Luiz Carlos Alcantara

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

29 Citações (Scopus)

Resumo

Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil.

Idioma originalEnglish
Páginas (de-até)2275-2283.e7
RevistaCell reports
Volume30
Número de emissão7
DOIs
Estado da publicaçãoPublicado - 18 fev. 2020
Publicado externamenteSim

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