Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay

Noelia Morel, Marta Giovanetti*, Vagner Fonseca, Analía Burgueño, Mauricio Lima, Emerson Castro, Natália R. Guimarães, Felipe C. M. Iani, Victoria Bormida, Maria Noel Cortinas, Viviana Ramas, Leticia Coppola, Ana I. Bento, Alexander Rosewell, Leticia Franco, Jairo Mendez Rico, José Lourenço, Luiz Carlos Junior Alcantara*, Hector Chiparelli*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

4 Transferências (Pure)

Resumo

This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context. The detection of multiple DENV-1 genotypes co-circulating in Uruguay underscores the necessity for proactive surveillance, particularly at borders, to prevent the introduction and dissemination of novel viral strains within the country and the region. This approach aids in facilitating prompt public health responses and intervention strategies, which are crucial in mitigating the impact of dengue outbreaks.

Idioma originalEnglish
Número do artigoe39246
Número de páginas4
RevistaHeliyon
Volume10
Número de emissão22
DOIs
Estado da publicaçãoPublicado - 30 nov. 2024

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