Gut as an alternative entry route for SARS-CoV-2: current evidence and uncertainties of productive enteric infection in COVID-19

Laure Alix Clerbaux*, Sally A. Mayasich, Amalia Munoz Pineiro, Helena Soares, Mauro Petrillo, Maria Cristina Albertini, Nicolas Lanthier, Lucia Grenga, Maria João Amorim

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

1 Citação (Scopus)
8 Transferências (Pure)

Resumo

The gut has been proposed as a potential alternative entry route for SARS-CoV-2. This was mainly based on the high levels of SARS-CoV-2 receptor expressed in the gastrointestinal (GI) tract, the observations of GI disorders (such as diarrhea) in some COVID-19 patients and the detection of SARS-CoV-2 RNA in feces. However, the underlying mechanisms remain poorly understood. It has been proposed that SARS-CoV-2 can productively infect enterocytes, damaging the intestinal barrier and contributing to inflammatory response, which might lead to GI manifestations, including diarrhea. Here, we report a methodological approach to assess the evidence supporting the sequence of events driving SARS-CoV-2 enteric infection up to gut adverse outcomes. Exploring evidence permits to highlight knowledge gaps and current inconsistencies in the literature and to guide further research. Based on the current insights on SARS-CoV-2 intestinal infection and transmission, we then discuss the potential implication on clinical practice, including on long COVID. A better understanding of the GI implication in COVID-19 is still needed to improve disease management and could help identify innovative therapies or preventive actions targeting the GI tract.
Idioma originalEnglish
Número do artigo5691
Número de páginas23
Revista Journal of Clinical Medicine
Volume11
Número de emissão19
DOIs
Estado da publicaçãoPublicado - out 2022

Impressão digital

Mergulhe nos tópicos de investigação de “Gut as an alternative entry route for SARS-CoV-2: current evidence and uncertainties of productive enteric infection in COVID-19“. Em conjunto formam uma impressão digital única.

Citação