Harnessing the power of CD8+ T-cells: identification and validation of peptides bound to major histocompatibility complex class I by immunopeptidomics

Camila R. R. Barbosa, Paulo Bettencourt

Resultado de pesquisarevisão de pares

1 Citação (Scopus)

Resumo

In most successful vaccines, the protection is based on antibodies able to target a pathogen containing a stable antigen repertoire. However, vaccines for some hard to treat diseases such as HIV, malaria and tuberculosis, are not included in this group and require T cells for protection. T cell induced vaccines have been increasingly attractive to provide solutions to these important diseases as well as to tackle cancer and non-transmissible diseases, where non-self antigens are generated. CD8+ T cells are the effector cells able to identify and destroy virally infected or cancer cells, upon recognition of foreign antigens. For decades, the identity of non-self antigens has been pursued in an attempt to activate a long lasting CD8+ T cell response against the pathology of interest. Diverse strategies have been employed to harness the power of cytotoxic CD8+ T cells. Here we describe the biology of MHC class-I antigen processing and presentation, and discuss the most important strategies to study peptide-specific CD8+ T cells. Moreover, we focus on the most sophisticated and recent technology to identify peptide sequences presented by MHC class-I molecules to CD8+ T cells: immunopeptidomics.
Idioma originalEnglish
Título da publicação do anfitriãoVaccinology and methods in vaccine research
Subtítulo da publicação do anfitriãoa volume in developments in immunology
EditoresRebecca Ashfield, Angus Nnamdi Oli, Charles Esimone, Linda Anagu
EditoraAcademic Press
Capítulo5
Páginas133-161
Número de páginas29
Volume1
ISBN (eletrónico)9780323914383
ISBN (impresso)9780323911467
DOIs
Estado da publicaçãoPublicado - 1 jan 2022

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