Identification of carbapenem-resistant Acinetobacter baumannii clones using infrared spectroscopy

Clara Sousa, Filipa Grosso, Luís Meirinhos-Soares, Luísa Peixe, João Lopes*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

29 Citações (Scopus)

Resumo

In this work we assessed the discriminatory ability of Fourier-transform Infrared Spectroscopy (FTIR) in 22 representative isolates from a collection of 318 carbapenem-hydrolyzing class D β -lactamases (CHDL)-producing Acinetobacter spp. (5 hospitals; 2001-2008) previously characterized by DNA-based typing methods. FTIR spectra were acquired with a Bruker spectrometer and analyzed with support of several chemometric tools. The results showed that FTIR spectroscopy was able to distinguish the main CHDL-producing Acinetobacter baumannii lineages causing infection in Portugal, the ST103 carrying blaOXA-58, ST98 carrying blaOXA-24/40and ST92 carrying blaOXA-23. Moreover, this study revealed distinctive phenotypic features of A. baumannii lineages causing infections that might justify different epidemic potential. Spectroscopy may arise as a low cost and easily to perform alternative for typing A. baumannii isolates.
Idioma originalEnglish
Páginas (de-até)287-294
Número de páginas8
RevistaJournal of Biophotonics
Volume7
Número de emissão5
DOIs
Estado da publicaçãoPublicado - mai. 2014
Publicado externamenteSim

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