The aim of this study was to investigate an eventual relationship between specific polymorphisms of the interleukin-1 gene cluster (IL1A-889, IL1B+3953) and of the IL1RN+2018 gene, and the complications of osseointegrated dental implants. Thirty Caucasian non-smokers patients carrying 36 implant overdentures were included and 125 implants were examined: 36 healthy (28.8%), 50 with perimucositis (43.2%) and 35 with peri-implantitis (28.0%). The IL1 classic combined genotype (IL1A-889, IL1B +3953) and the extended genotype (association with IL1RN +2018) were present in 6 subjects (20.0%), all affected by peri-implant diseases. The carriage rate of IL1RN allele 2 was 40.0% and 53.0%, in healthy and affected subjects, respectively. It is reasonable to expect higher risk for peri-implant diseases in positive risk genotype patients. More studies are necessary to confirm the associated risk. The combination of gene biomarkers with conventional risk factors allows stratifying populations and provides an added value in establishing individual preventive programs.
|Nome||Biodental Engineering III - Proceedings of the 3rd International Conference on Biodental Engineering, BIODENTAL 2014|
|Conferência||3rd International Conference on Biodental Engineering, BIODENTAL 2014|
|Período||22/06/14 → 23/06/14|