TY - JOUR
T1 - Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
AU - COVIDsortium Investigators
AU - COVIDsortium Immune Correlates Network
AU - Reynolds, Catherine J.
AU - Pade, Corinna
AU - Gibbons, Joseph M.
AU - Otter, Ashley D.
AU - Lin, Kai Min
AU - Sandoval, Diana Muñoz
AU - Pieper, Franziska P.
AU - Butler, David K.
AU - Liu, Siyi
AU - Joy, George
AU - Forooghi, Nasim
AU - Treibel, Thomas A.
AU - Manisty, Charlotte
AU - Moon, James C.
AU - Semper, Amanda
AU - Brooks, Tim
AU - McKnight, Áine
AU - Altmann, Daniel M.
AU - Boyton, Rosemary J.
AU - Abbass, Hakam
AU - Abiodun, Aderonke
AU - Alfarih, Mashael
AU - Alldis, Zoe
AU - Amin, Oliver E.
AU - Andiapen, Mervyn
AU - Artico, Jessica
AU - Augusto, João B.
AU - Baca, Georgina L.
AU - Bailey, Sasha N.L.
AU - Bhuva, Anish N.
AU - Boulter, Alex
AU - Bowles, Ruth
AU - Bracken, Olivia V.
AU - O'Brien, Ben
AU - Bullock, Natalie
AU - Captur, Gabriella
AU - Carr, Olivia
AU - Champion, Nicola
AU - Chan, Carmen
AU - Chandran, Aneesh
AU - Coleman, Tom
AU - de Sousa, Jorge Couto
AU - Couto-Parada, Xose
AU - Cross, Eleanor
AU - Cutino-Moguel, Teresa
AU - D'Arcangelo, Silvia
AU - Davies, Rhodri H.
AU - Douglas, Brooke
AU - Di Genova, Cecilia
AU - Dieobi-Anene, Keenan
N1 - Publisher Copyright:
© 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY)
PY - 2022/7/15
Y1 - 2022/7/15
N2 - The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
AB - The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
UR - http://www.scopus.com/inward/record.url?scp=85132254530&partnerID=8YFLogxK
U2 - 10.1126/science.abq1841
DO - 10.1126/science.abq1841
M3 - Article
C2 - 35699621
AN - SCOPUS:85132254530
SN - 0036-8075
VL - 377
JO - Science
JF - Science
IS - 6603
M1 - eabq1841
ER -