In situ enabling approaches for tissue regeneration: current challenges and new developments

Juliana R. Dias*, Nilza Ribeiro, Sara Baptista-Silva, Ana Rita Costa-Pinto, Nuno Alves, Ana L. Oliveira

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

39 Citações (Scopus)
13 Transferências (Pure)

Resumo

In situ tissue regeneration can be defined as the implantation of tissue-specific biomaterials (by itself or in combination with cells and/or biomolecules) at the tissue defect, taking advantage of the surrounding microenvironment as a natural bioreactor. Up to now, the structures used were based on particles or gels. However, with the technological progress, the materials’ manipulation and processing has become possible, mimicking the damaged tissue directly at the defect site. This paper presents a comprehensive review of current and advanced in situ strategies for tissue regeneration. Recent advances to put in practice the in situ regeneration concept have been mainly focused on bioinks and bioprinting techniques rather than the combination of different technologies to make the real in situ regeneration. The limitation of conventional approaches (e.g., stem cell recruitment) and their poor ability to mimic native tissue are discussed. Moreover, the way of advanced strategies such as 3D/4D bioprinting and hybrid approaches may contribute to overcome the limitations of conventional strategies are highlighted. Finally, the future trends and main research challenges of in situ enabling approaches are discussed considering in vitro and in vivo evidence.
Idioma originalEnglish
Número do artigo85
Páginas (de-até)1-20
Número de páginas20
RevistaFrontiers in Bioengineering and Biotechnology
Volume8
DOIs
Estado da publicaçãoPublicado - 18 fev. 2020

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