Is decellularized rabbit dermis a viable option for skin wound healing and regeneration?

Burn wounds remain a major clinical challenge, requiring effective coverage to restore the skin barrier and support healing. Autologous grafts are the standard treatment but are limited in deep or extensive burns [1]. Decellularized allografts and xenografts offer alternatives by removing immunogenic material while preserving ECM components [2]. Considering that xenografts source availability is significantly higher and free of ethical concerns, this study describes for the first time a protocol for decellularizing rabbit dermis, leveraging a valuable agro-food by-product that exceeds 5000 skins/day at the world-leading company Cortadoria Nacional de Pêlo, and studies its potential for skin regeneration.