Is there a role for adult non-cultivated bone marrow stem cells in ACL reconstruction?

Alcindo Silva*, Ricardo Sampaio, Rui Fernandes, Elisabete Pinto

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

64 Citações (Scopus)

Resumo

Purpose: To assess by magnetic resonance imaging (MRI) if adult non-cultivated bone marrow stem cells accelerate tendon-to-bone healing in the femoral tunnel, after hamstring anterior cruciate ligament (ACL) reconstruction. Methods: Forty-three patients underwent ACL reconstruction and were prospectively randomized into two groups: 20 patients in the experimental group (group A) with adult non-cultivated bone marrow stem cells and 23 patients in the control group (group B) without adult non-cultivated bone marrow stem cells. All patients underwent MRI of the knee at three months after surgery to evaluate the signal-to-noise ratio of the interzone. Results: There was no difference in the signal-to-noise ratio of the interzone on MRI between the experimental and the control group. Conclusions: Adult non-cultivated bone marrow stem cells do not seem to accelerate graft-to-bone healing in ACL reconstruction. The clinical relevance of this finding is that adult non-cultivated bone marrow stem cells apparently have a limited role in ACL reconstruction. Level of evidence: II.
Idioma originalEnglish
Páginas (de-até)66-71
Número de páginas6
RevistaKnee Surgery, Sports Traumatology, Arthroscopy
Volume22
Número de emissão1
DOIs
Estado da publicaçãoPublicado - 1 jan. 2014
Publicado externamenteSim

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