TY - JOUR
T1 - Longitudinal changes in fecal calprotectin levels among pregnant women with and without inflammatory bowel disease and their babies
AU - The Mount Sinai Road to Prevention Study Group
AU - Kim, Eun Soo
AU - Tarassishin, Leonid
AU - Eisele, Caroline
AU - Barre, Amelie
AU - Nair, Nilendra
AU - Rendon, Alexa
AU - Hawkins, Kelly
AU - Debebe, Anketse
AU - White, Sierra
AU - Thjømøe, Anne
AU - Mørk, Einar
AU - Bento-Miranda, Mario
AU - Panchal, Hinaben
AU - Agrawal, Manasi
AU - Patel, Anish
AU - Chen, Ching Lynn
AU - Kornbluth, Asher
AU - George, James
AU - Legnani, Peter
AU - Maser, Elana
AU - Loudon, Holly
AU - Mella, Maria Teresa
AU - Stone, Joanne
AU - Dubinsky, Marla
AU - Sabino, João
AU - Torres, Joana
AU - Colombel, Jean Frederic
AU - Peter, Inga
AU - Hu, Jianzhong
N1 - Funding Information:
Funding This study was supported by the International Organization for the Study of Inflammatory Bowel Disease (to Inga Peter and Jean-Frederic Colombel) and The Crohn’s and Colitis Foundation (to Inga Peter, Joana Torres, and Jean-Frederic Colombel). CALPRO AS provided calprotectin enzyme-linked immunosorbent assay kits at no cost.
Publisher Copyright:
© 2021
PY - 2021/3
Y1 - 2021/3
N2 - Background & Aims: The effect of pregnancy on inflammatory bowel disease (IBD) remains poorly understood. We aimed to monitor intestinal inflammation using fecal calprotectin (FC) in pregnant women and their babies during early life. Methods: Pregnant women with or without IBD and their infants were prospectively enrolled. FC levels were measured at each trimester of pregnancy and in babies throughout the first 3 years of life. Repeated-measures analysis was applied to investigate changes in FC levels while adjusting for confounders. The FC levels were correlated with the bacterial abundance in both mothers and babies. Results: Six hundred and fourteen fecal samples from 358 mothers (98 with IBD) and 1005 fecal samples from 289 infants (76 born to IBD mothers) were analyzed. Pregnant Patients with IBD maintained higher FC levels through pregnancy compared with controls (P = 7.5 × 10–54). FC gradually increased in controls and declined in Patients with IBD throughout pregnancy (P for interaction = 5.8 × 10–7). Babies born to mothers with IBD presented with significantly higher FC levels than those born to controls up to 3 years of age, after adjusting for sex, delivery mode, feeding behavior, and antibiotics exposure (2 weeks to 3 months of age, P = .015; 12–36 months of age, P = .00003). Subdoligranulum, Roseburia, Fusicatenibacter, and Alistipes negatively correlated, and Streptococcus, Prevotella, Escherichia-Shigella, and Bifidobacterium positively correlated with maternal FC levels at T3. Faecalibacterium, Bifidobacterium, and Alistipes showed negative correlations, and Streptococcus were positively correlated with FC levels within 3 months of birth. Conclusions: Pregnancy is associated with decreased inflammatory activity in mothers with IBD. Higher FC levels in babies born to mothers with IBD suggest subclinical inflammation in early life, the long-term consequences of which are uncertain.
AB - Background & Aims: The effect of pregnancy on inflammatory bowel disease (IBD) remains poorly understood. We aimed to monitor intestinal inflammation using fecal calprotectin (FC) in pregnant women and their babies during early life. Methods: Pregnant women with or without IBD and their infants were prospectively enrolled. FC levels were measured at each trimester of pregnancy and in babies throughout the first 3 years of life. Repeated-measures analysis was applied to investigate changes in FC levels while adjusting for confounders. The FC levels were correlated with the bacterial abundance in both mothers and babies. Results: Six hundred and fourteen fecal samples from 358 mothers (98 with IBD) and 1005 fecal samples from 289 infants (76 born to IBD mothers) were analyzed. Pregnant Patients with IBD maintained higher FC levels through pregnancy compared with controls (P = 7.5 × 10–54). FC gradually increased in controls and declined in Patients with IBD throughout pregnancy (P for interaction = 5.8 × 10–7). Babies born to mothers with IBD presented with significantly higher FC levels than those born to controls up to 3 years of age, after adjusting for sex, delivery mode, feeding behavior, and antibiotics exposure (2 weeks to 3 months of age, P = .015; 12–36 months of age, P = .00003). Subdoligranulum, Roseburia, Fusicatenibacter, and Alistipes negatively correlated, and Streptococcus, Prevotella, Escherichia-Shigella, and Bifidobacterium positively correlated with maternal FC levels at T3. Faecalibacterium, Bifidobacterium, and Alistipes showed negative correlations, and Streptococcus were positively correlated with FC levels within 3 months of birth. Conclusions: Pregnancy is associated with decreased inflammatory activity in mothers with IBD. Higher FC levels in babies born to mothers with IBD suggest subclinical inflammation in early life, the long-term consequences of which are uncertain.
KW - Fecal calprotectin
KW - Inflammatory bowel disease
KW - Microbiome
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85102109893&partnerID=8YFLogxK
U2 - 10.1053/j.gastro.2020.11.050
DO - 10.1053/j.gastro.2020.11.050
M3 - Article
C2 - 33307026
AN - SCOPUS:85102109893
SN - 0016-5085
VL - 160
SP - 1118-1130.e3
JO - Gastroenterology
JF - Gastroenterology
IS - 4
ER -