Magnesium incorporation into β-TCP reduced its in vivo resorption by decreasing parathormone production

Debora H. Yassuda, Neusa F. M. Costa, Gustavo O. Fernandes, Gutemberg G. Alves, José M. Granjeiro*, Glória de A. Soares

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

10 Citações (Scopus)

Resumo

Beta-tricalcium phosphate (β-TCP), one of the most widely used bioresorbable materials for bone therapy, can be doped with magnesium ions, generating β-TCMP. The objectives of this work were to evaluate, on a murine dental alveolus grafting model, the biocompatibility of β-TCP and β-TMCP granules by histomorphometric analysis, as well as the impact on plasmatic levels of receptor activator of nuclear factor κB ligand (RANK-L), osteoprotegerin (OPG), osteocalcin, osteopontin, and parathormone (PTH) during bone repair, using Luminex multiplexing technology. After grafting for 42 days, β-TCP grafted group presented higher bioresorption and induced more newly formed bone than β-TCMP (p < 0.05). β-TCP grafting also induced higher plasmatic levels of RANK-L, compared to β-TCMP and control (blood clot) groups at 21st day (p < 0.05). PTH, which remained at low levels in control group, presented a time-dependent increase in grafted groups, attaining significantly higher levels with β-TCP by the 42nd day (p < 0.05). RANK-L/OPG ratio increased on β-TCP group and attained a peak on the 21st day. In conclusion, β-TCP granules were more bioresorbable and osteogenic than β-TCMP granules, and the resorption of both materials might have been affected by osteoclastogenesis modulated by changes in the plasmatic levels of PTH and RANK-L.
Idioma originalEnglish
Páginas (de-até)1986-1993
Número de páginas8
RevistaJournal of Biomedical Materials Research - Part A
Volume101 A
Número de emissão7
DOIs
Estado da publicaçãoPublicado - jul 2013
Publicado externamenteSim

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