Modified chicha gum by acetylation for antimicrobial and antiparasitic applications: characterization and biological properties

Elton Marks Araujo Braz, Solranny Carla Cavalcante Costa Silva, Carla Adriana Rodrigues Sousa Brito, Fernando Aécio Amorim Carvalho, Michel Muálem Moraes Alves, Humberto Medeiros Barreto, Durcilene Alves Silva, Rui Magalhães, Ana Leite Oliveira, Edson C. Silva-Filho*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

14 Citações (Scopus)

Resumo

It was developed a material to act as an antimicrobial and antiparasitic agent through a modification reaction in the gum structure extracted from the plant Sterculia striata. This material was characterized, the oxidant activity was evaluated and the antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Salmonella Typhimurium and Klebsiella pneumoniae was investigated, in addition to the effect against Leishmania amazonensis, testing its acute toxicity and its cytotoxicity in human cells. Characterization techniques proved the success of chemical modification. The modification led to an increase in antioxidant activity, with excellent antibacterial activity, reaching almost 100% inhibition for P. aeruginosa and S. Typhimurium, and inhibitory effect above 70% against L. amazonensis, with an affinity far superior to the parasite than macrophages. The derivative showed no acute toxicity, it was non-hemolytic, increased cell viability in macrophages and fibroblasts, and stimulated cell proliferation of keratinocytes, thus being a strong candidate to be used as an antimicrobial and antiparasitic agent in biomedical applications.
Idioma originalEnglish
Páginas (de-até)1177-1188
Número de páginas12
RevistaInternational Journal of Biological Macromolecules
Volume160
DOIs
Estado da publicaçãoPublicado - 1 out. 2020

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