NAPRT expression regulation mechanisms: novel functions predicted by a bioinformatics approach

Sara Duarte-Pereira*, Olga Fajarda, Sérgio Matos, José Luís Oliveira, Raquel Monteiro Silva

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

1 Transferências (Pure)

Resumo

The nicotinate phosphoribosyltransferase (NAPRT) gene has gained relevance in the research of cancer therapeutic strategies due to its main role as a NAD biosynthetic enzyme. NAD metabolism is an attractive target for the development of anti-cancer therapies, given the high energy requirements of proliferating cancer cells and NAD-dependent signaling. A few studies have shown that NAPRT expression varies in different cancer types, making it imperative to assess NAPRT expression and functionality status prior to the application of therapeutic strategies targeting NAD. In addition, the recent finding of NAPRT extracellular form (eNAPRT) suggested the involvement of NAPRT in inflammation and signaling. However, the mechanisms regulating NAPRT gene expression have never been thoroughly addressed. In this study, we searched for NAPRT gene expression regulatory mechanisms in transcription factors (TFs), RNA binding proteins (RBPs) and microRNA (miRNAs) databases. We identified several potential regulators of NAPRT transcription activation, downregulation and alternative splicing and performed GO and expression analyses. The results of the functional analysis of TFs, RBPs and miRNAs suggest new, unexpected functions for the NAPRT gene in cell differentiation, development and neuronal biology.
Idioma originalEnglish
Número do artigo2022
Número de páginas16
RevistaGenes
Volume12
Número de emissão12
DOIs
Estado da publicaçãoPublished - dez 2021

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