New and efficient bioactive glass compositions for controlling endodontic pathogens

Bruna L. Correia; Ana T. P. C. Gomes; Rita Noites; José M. F. Ferreira; Ana S. Duarte

doi:10.3390/nano12091577

New and efficient bioactive glass compositions for controlling endodontic pathogens

Bruna L. Correia^*, Ana T. P. C. Gomes^*, Rita Noites^*, José M. F. Ferreira^*, Ana S. Duarte^*

^*Autor correspondente para este trabalho

Resultado de pesquisa › revisão de pares

11 Citações (Scopus)

45 Transferências (Pure)

Resumo

Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol–gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments (E. faecalis and C. albicans) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of E. faecalis after 48 h of incubation, and all BG samples have a significant effect on C. albicans survival.

Idioma original	English
Número do artigo	1577
Número de páginas	16
Revista	Nanomaterials
Volume	12
Número de emissão	9
DOIs	https://doi.org/10.3390/nano12091577
Estado da publicação	Publicado - 1 mai. 2022

Acesso ao documento

10.3390/nano12091577Licença:

43693106Final published version, 2,44 MBLicença:

http://hdl.handle.net/10400.14/37702Licença:

Outros arquivos e links

Link to publication in Scopus

1 Terminados
2 Ativos

CEEC Institucional 2018 - CIIS - Professor Auxiliar 1 - ASD
Duarte, A. S. (PI)
Fundação para a Ciência e a Tecnologia
1/03/21 → 27/07/25
Projeto
CEEC Institucional 2018 - CIIS: CEEC Institucional 2018 - CIIS - Investigador Auxiliar - ATPCG
Gomes, A. P. (PI)
Fundação para a Ciência e a Tecnologia
3/01/21 → 30/06/25
Projeto
CIIS: Centro de Investigação Interdisciplinar em Saúde
Barros, M. (PI), Rosa, N. (Investigador), Correia, M. J. (Investigador), Caldas, A. C. (Investigador), Amado, J. C. (Investigador), Figueiredo, A. S. (Investigador), Esteves, A. C. (Investigador), Mineiro, A. (Investigador), Abreu, A. M. (Investigador), Duarte, A. S. (Investigador), Almeida, S. F. (Investigador), Correia, A. (Investigador), Moura, A. (Investigador), Almeida, A. (Investigador), Araújo, B. (Investigador), Moura-Netto, C. (Investigador), Ferrito, C. (Investigador), Pais-Vieira, C. (Investigador), Festas, C. (Investigador), Marques-Vieira, C. (Investigador), Catré, D. (Investigador), Nunes, E. (Investigador), Jesus, É. (Investigador), Ribeiro, F. (Investigador), Rosário, F. (Investigador), Fernandes, G. (Investigador), Rato, J. R. (Bolseiro), Salgado, J. R. (Investigador), Neves-Amado, J. (Investigador), Amendoeira, J. (Investigador), Sá, L. (Investigador), Capelas, M. L. (Investigador), Vieira, M. M. (Investigador), Nunes, M. V. S. (Investigador), Cardoso, M. (Investigador), Veiga, N. J. (Investigador), Fonseca, P. (Investigador), Correia, P. N. (Investigador), Couto, P. (Investigador), Pontífice-Sousa, P. (Investigador), Ravasco, P. (Investigador), Carvalho, P. V. D. (Investigador), Alves, P. (Investigador), Melo, P. (Investigador), Silva, R. (Investigador), Canaipa, R. (Investigador), Noites, R. (Investigador), Rio, R. (Investigador), Almeida, S. (Investigador), Deodato, S. (Investigador), Caldeira, S. (Investigador), Silva, S. (Investigador), Borges, T. (Investigador), Silva, V. (Investigador), Charepe, Z. (Investigador), Rodrigues-Pires, F. (Voluntário), Veludo, F. (Investigador), Carmo, H. (Bolseiro), Romeiro, J. (Estudante), Melo, M. (Investigador), Braga, M. (Investigador), Amaral, T. (Investigador), Moreira, M. A. (Investigador), Guerra, N. (Estudante), Santos, P. (Investigador), Paço, S. (Estudante), Lynce, S. (Bolseiro), Miguel, S. (Estudante), Costa, T. (Investigador), Silva-Neves, V. (Investigador), Silva, A. (Investigador), Carvalho, A. R. (Investigador), Almeida, B. (Investigador), Figueiredo, C. (Investigador), Esteves, E. (Bolseiro), Araújo, F. M. (Investigador), Garcia, J. G. (Investigador), Santos, L. (Investigador), Santos, N. M. D. (Investigador), Lopes, P. (Investigador), Bornes, R. (Investigador), Silva, R. (Investigador), Costa, S. (Investigador), Silva, S. M. (Investigador), Marques, T. (Investigador), Almeida, A. (Investigador), Santos, M. (Bolseiro), Santos, P. (Investigador), Miguel, S. (Investigador), Mendes, K. (Investigador), Gomes, A. P. (Investigador), Henriques, J. M. P. (Investigador), Costa, H. A. F. P. (Investigador) & Ribeiro, P. (Investigador)
Fundação para a Ciência e a Tecnologia
1/01/20 → 31/12/24
Projeto

Citação

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title = "New and efficient bioactive glass compositions for controlling endodontic pathogens",

abstract = "Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol–gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments (E. faecalis and C. albicans) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of E. faecalis after 48 h of incubation, and all BG samples have a significant effect on C. albicans survival.",

keywords = "Bioactive glass, Candida albicans, Enterococcus faecalis, Intracanal medication, Reinfection, Root canal treatment",

author = "Correia, {Bruna L.} and Gomes, {Ana T. P. C.} and Rita Noites and Ferreira, {Jos{\'e} M. F.} and Duarte, {Ana S.}",

note = "Funding Information: This work was developed within the scope of the projects of the CICECO?Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019 and of the CIIS-UCP, Viseu, FCT Ref. UIDB/04279/2020. Thanks are also due to FCT and UCP for the CEEC institutional financing of Ana T.P.C. Gomes (CEECINST/00137/2018/CP1520/CT0022) and Ana Sofia Duarte (CEECINST/00137/ 2018/CP1520/CT0013). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/nano12091577",

language = "English",

volume = "12",

journal = "Nanomaterials",

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AU - Correia, Bruna L.

AU - Gomes, Ana T. P. C.

AU - Noites, Rita

AU - Ferreira, José M. F.

AU - Duarte, Ana S.

N1 - Funding Information: This work was developed within the scope of the projects of the CICECO?Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019 and of the CIIS-UCP, Viseu, FCT Ref. UIDB/04279/2020. Thanks are also due to FCT and UCP for the CEEC institutional financing of Ana T.P.C. Gomes (CEECINST/00137/2018/CP1520/CT0022) and Ana Sofia Duarte (CEECINST/00137/ 2018/CP1520/CT0013). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol–gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments (E. faecalis and C. albicans) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of E. faecalis after 48 h of incubation, and all BG samples have a significant effect on C. albicans survival.

AB - Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol–gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments (E. faecalis and C. albicans) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of E. faecalis after 48 h of incubation, and all BG samples have a significant effect on C. albicans survival.

KW - Bioactive glass

KW - Candida albicans

KW - Enterococcus faecalis

KW - Intracanal medication

KW - Reinfection

KW - Root canal treatment

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New and efficient bioactive glass compositions for controlling endodontic pathogens

Resumo

Acesso ao documento

Outros arquivos e links

Impressão digital

Projetos

CEEC Institucional 2018 - CIIS - Professor Auxiliar 1 - ASD

CEEC Institucional 2018 - CIIS: CEEC Institucional 2018 - CIIS - Investigador Auxiliar - ATPCG

CIIS: Centro de Investigação Interdisciplinar em Saúde

Citação