New CTX‐M group conferring β‐lactam resistance: a compendium of phylogenetic insights from biochemical, molecular, and structural biology

Jacinta Mendonça*, Carla Guedes*, Carina Silva*, Sara Sá*, Marco Oliveira*, Gustavo Accioly*, Pilar Baylina*, Pedro Barata*, Cláudia Pereira*, Ruben Fernandes*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

7 Citações (Scopus)
9 Transferências (Pure)

Resumo

The production of extended‐spectrum β‐lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX‐M enzymes appear as the most efficient in terms of dissemination in different epidemiological contexts. CTX‐M enzymes exhibit a striking plas-ticity, with a large number of allelic variants distributed in several sublineages, which can be associated with functional heterogeneity of clinical relevance. This observational analytical study provides an update of this family, currently with more than 200 variants described, from a phylogenetic, molecular, and structural point of view through homology in amino acid sequences. Our data, combined with described literature, provide phylogenetic and structural evidence of a new group. Thus, herein, we propose six groups among CTX‐M enzymes: the already stablished CTX‐M‐1, CTX‐M‐2, CTX‐M‐8, CTX‐M‐9, and CTX‐M‐25 clusters, as well as CTX‐M‐151 as the new cluster.
Idioma originalEnglish
Número do artigo256
Número de páginas16
RevistaBiology
Volume11
Número de emissão2
DOIs
Estado da publicaçãoPublicado - fev. 2022

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