New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeeriana

Marta Neves; Rui Morais; Stefan Gafner; Helen Stoeckli-Evans; K. Hostettmann

doi:10.1016/S0031-9422(98)00648-7

New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeeriana

Marta Neves, Rui Morais^*, Stefan Gafner, Helen Stoeckli-Evans, K. Hostettmann

^*Autor correspondente para este trabalho

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40 Citações (Scopus)

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Resumo

Three new sesquiterpene lactones (acetyltrifloculoside, 8,15- acetylsalonitenolide and 8-acetylsalonitenolide) and two known sesquiterpene lactones were isolated from a dichloromethane extract of the Portuguese liverwort Targionia lorbeeriana. Their structures were established by spectroscopic methods (EI and D/CI mass spectroscopy, ¹H and ¹³C NMR) and that of acetyltrifloculoside was confirmed by X-ray crystallography. The three isolated guaianolide sesquiterpene lactones presented antifungal activity against Cladosporium cucumerinum and larvicidal activity against Aedes aegypti. Only one of the isolated lactones presented activity against Candida albicans.

Idioma original	English
Páginas (de-até)	967-972
Número de páginas	6
Revista	Phytochemistry
Volume	50
Número de emissão	6
DOIs	https://doi.org/10.1016/S0031-9422(98)00648-7
Estado da publicação	Publicado - 20 mar. 1999

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10.1016/S0031-9422(98)00648-7

19830321Accepted author manuscript, 256 KBLicença:

http://hdl.handle.net/10400.14/6464Licença:

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Citação

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title = "New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeeriana",

abstract = "Three new sesquiterpene lactones (acetyltrifloculoside, 8,15- acetylsalonitenolide and 8-acetylsalonitenolide) and two known sesquiterpene lactones were isolated from a dichloromethane extract of the Portuguese liverwort Targionia lorbeeriana. Their structures were established by spectroscopic methods (EI and D/CI mass spectroscopy, 1H and 13C NMR) and that of acetyltrifloculoside was confirmed by X-ray crystallography. The three isolated guaianolide sesquiterpene lactones presented antifungal activity against Cladosporium cucumerinum and larvicidal activity against Aedes aegypti. Only one of the isolated lactones presented activity against Candida albicans.",

keywords = "Bioassay, Liverwort, Phytochemistry, Sesquiterpene lactones, T. lorbeeriana, Targionaceae, Terpenoids",

author = "Marta Neves and Rui Morais and Stefan Gafner and Helen Stoeckli-Evans and K. Hostettmann",

year = "1999",

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doi = "10.1016/S0031-9422(98)00648-7",

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TY - JOUR

T1 - New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeeriana

AU - Neves, Marta

AU - Morais, Rui

AU - Gafner, Stefan

AU - Stoeckli-Evans, Helen

AU - Hostettmann, K.

PY - 1999/3/20

Y1 - 1999/3/20

N2 - Three new sesquiterpene lactones (acetyltrifloculoside, 8,15- acetylsalonitenolide and 8-acetylsalonitenolide) and two known sesquiterpene lactones were isolated from a dichloromethane extract of the Portuguese liverwort Targionia lorbeeriana. Their structures were established by spectroscopic methods (EI and D/CI mass spectroscopy, 1H and 13C NMR) and that of acetyltrifloculoside was confirmed by X-ray crystallography. The three isolated guaianolide sesquiterpene lactones presented antifungal activity against Cladosporium cucumerinum and larvicidal activity against Aedes aegypti. Only one of the isolated lactones presented activity against Candida albicans.

AB - Three new sesquiterpene lactones (acetyltrifloculoside, 8,15- acetylsalonitenolide and 8-acetylsalonitenolide) and two known sesquiterpene lactones were isolated from a dichloromethane extract of the Portuguese liverwort Targionia lorbeeriana. Their structures were established by spectroscopic methods (EI and D/CI mass spectroscopy, 1H and 13C NMR) and that of acetyltrifloculoside was confirmed by X-ray crystallography. The three isolated guaianolide sesquiterpene lactones presented antifungal activity against Cladosporium cucumerinum and larvicidal activity against Aedes aegypti. Only one of the isolated lactones presented activity against Candida albicans.

KW - Bioassay

KW - Liverwort

KW - Phytochemistry

KW - Sesquiterpene lactones

KW - T. lorbeeriana

KW - Targionaceae

KW - Terpenoids

UR - http://www.scopus.com/inward/record.url?scp=0032892231&partnerID=8YFLogxK

U2 - 10.1016/S0031-9422(98)00648-7

DO - 10.1016/S0031-9422(98)00648-7

M3 - Article

AN - SCOPUS:0032892231

SN - 0031-9422

VL - 50

SP - 967

EP - 972

JO - Phytochemistry

JF - Phytochemistry

IS - 6

ER -

New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeeriana

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