O4 - Exploring the biological properties and regenerative potential of biomaterials using cell culture models

Ana Sofia Duarte*, Bruna L. Correia, Maria Bartolomeu, Karina Mendes, Ana T. P. C. Gomes

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

10 Transferências (Pure)

Resumo

Life expectancy has improved signifcantly and, along with the declining birthrate, has contributed to the aging of populations, especially in industrialized countries. Alas, aging is intrinsically associated with the incidence of health problems including bone and tooth loss that require suitable solutions to support the quality of life. To meet these demands, signifcant research eforts have been undertaken to develop novel biomaterials, both orthopedic and dental implants. The feld of biomaterials for bone tissue engineering is increasingly evolving. The most recent generations of biomaterials have increasingly more activity and interaction with the biological environment and stimulate the regeneration of functional tissue. Natural polymers and compounds have been combined with each other to improve workability and are strategically integrated with ceramics or bioactive glasses to reinforce the structure of the fnal system, thus producing composites with a better mechanical performance. Our research group has been focused on the biological characterization of diferent added-value materials and composites, namely by evaluating their antimicrobial, biocompatibility, and regenerative properties. Some of our recent work results allowed us to conclude that marine fungal extracts, as well as sol–gel-derived bioactive glass nanoparticles, have inhibitory efects on the growth of C. albicans and E. faecalis (main pathogens in persistent root canal infections). Additionally, we have characterized cuttlefsh bone powders for endodontic applications. We are also committed to developing strategies for monitoring cell response to these biomaterials at the molecular level that could be used to follow infammation and osteoconduction.
Idioma originalEnglish
Páginas3-3
Número de páginas1
Estado da publicaçãoPublicado - mar. 2023
EventoNational Meeting of the Center for Interdisciplinary Research in Health (CIIS) - Universidade Católica Portuguesa, Sintra
Duração: 31 mar. 20231 abr. 2023

Seminário

SeminárioNational Meeting of the Center for Interdisciplinary Research in Health (CIIS)
País/TerritórioPortugal
CidadeSintra
Período31/03/231/04/23

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