Oral intake of carboxymethyl-glucan (CM-G) from yeast (Saccharomyces uvarum) reduces malondialdehyde levels in healthy men

Vilma Barbosa Da Silva Araújo, Adma Nadja Ferreira De Melo, Neyrijane Targino De Souza, Vânia Maria Barboza Da Silva, Raul H. Castro-Gomez, Alexandre Sérgio Silva, Evandro Leite De Souza, Marciane Magnani*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

13 Citações (Scopus)

Resumo

Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1→3)(1→6) glucan, a well-known immunostimulant and antioxidant compound. In this experimental, randomized and placebo-controlled study, the effects of oral CM-G intake over a 60-day period on the peripheral blood, cholesterol, glycemic index and malondialdehyde (MDA) levels of healthy men was assessed. The CM-G was obtained from spent brewer's yeast (S. uvarum) with DS 0.8 and molecular weight of 2.2 × 105 Da. Following CM-G administration, no changes were observed in red and white blood cell, hematocrit, hemoglobin and platelet counts, or in cholesterol and glycemic indices. After 30 days of CM-G administration, the MDA levels decreased significantly (p ≤ 0.05) in men receiving CM-G. The results showed for the first time that CM-G may act as an adjuvant in preventing oxidative damage in healthy humans.

Idioma originalEnglish
Páginas (de-até)14950-14958
Número de páginas9
RevistaMolecules
Volume20
Número de emissão8
DOIs
Estado da publicaçãoPublicado - 1 ago. 2015
Publicado externamenteSim

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