P9 - Antimicrobial properties and bioactivity potential of smart nanoparticles for dental applications

Bruna L. Correia, Moslem Malekshiri, Maria Bartolomeu, Virgília Silva, Ana Oliveira, Rita Noites, Miguel Cardoso, Karina Mendes, Ana T. P. C. Gomes, Ana Sofia Duarte

Resultado de pesquisarevisão de pares

14 Transferências (Pure)

Resumo

Tooth decay is one of the greatest causes of tooth loss in the world. This not only afects the patient’s quality of life but also carries an economic burden associated with the need for multiple reinterventions. Endodontic treatment aims to preserve teeth by cleaning, disinfecting and flling/sealing the root canal. Despite the high success rate of endodontic treatment, failures do occur in a large number of cases. Several new biomaterials for dentistry have been developed, however their bioactivity is often misunderstood. Our work focuses on the biological characterization of novel bioactive glass nanoparticles, including the evaluation of their antimicrobial and biocompatibility properties. Candida albicans (ATCC 11225) and Enterococcus faecalis (ATCC 29212) were included to evaluate the antimicrobial potential by the drop plate method [1]. The cytotoxicity was tested using the MC3T3-E1 cell line, through the resazurin reduction assay. The novel bioactive glass nanoparticles demonstrated antimicrobial activity against C. albicans and E. faecalis, being able to inhibit their growth but also, in some incubation times, decreased the survival of these microorganisms. After 24 h of incubation of MC3T3-E1 osteoblast cells with bioactive glass nanoparticles conditioned medium, around 48% cell viability was achieved. These novel bioactive glass nanoparticles have shown promising properties which may fnd applications on diferent areas of clinical dentistry.
Idioma originalEnglish
Páginas12-12
Número de páginas1
Estado da publicaçãoPublicado - mar. 2023
EventoNational Meeting of the Center for Interdisciplinary Research in Health (CIIS) - Universidade Católica Portuguesa, Sintra
Duração: 31 mar. 20231 abr. 2023

Seminário

SeminárioNational Meeting of the Center for Interdisciplinary Research in Health (CIIS)
País/TerritórioPortugal
CidadeSintra
Período31/03/231/04/23

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