Percent atheroma volume: optimal variable to report whole-heart atherosclerotic plaque burden with coronary CTA, the PARADIGM study

Alexander R. van Rosendael; Fay Y. Lin; Xiaoyue Ma; Inge J. van den Hoogen; Umberto Gianni; Omar Al Hussein; Subhi J. Al'Aref; Jessica M. Peña; Daniele Andreini; Mouaz H. Al-Mallah; Matthew J. Budoff; Filippo Cademartiri; Kavitha Chinnaiyan; Jung Hyun Choi; Edoardo Conte; Hugo Marques; Pedro de Araújo Gonçalves; Ilan Gottlieb; Martin Hadamitzky; Jonathon A. Leipsic; Erica Maffei; Gianluca Pontone; Gilbert L. Raff; Sanghoon Shin; Yong Jin Kim; Byoung Kwon Lee; Eun Ju Chun; Ji Min Sung; Sang Eun Lee; Daniel S. Berman; Renu Virmani; Habib Samady; Peter H. Stone; Jagat Narula; Jeroen J. Bax; Leslee J. Shaw; James K. Min; Hyuk Jae Chang

doi:10.1016/j.jcct.2020.01.012

Percent atheroma volume: optimal variable to report whole-heart atherosclerotic plaque burden with coronary CTA, the PARADIGM study

Alexander R. van Rosendael
, Fay Y. Lin
, Xiaoyue Ma
, Inge J. van den Hoogen
, Umberto Gianni
, Omar Al Hussein
, Subhi J. Al'Aref
, Jessica M. Peña
, Daniele Andreini
, Mouaz H. Al-Mallah
, Matthew J. Budoff
, Filippo Cademartiri
, Kavitha Chinnaiyan
, Jung Hyun Choi
, Edoardo Conte
, Hugo Marques
, Pedro de Araújo Gonçalves
, Ilan Gottlieb
, Martin Hadamitzky
, Jonathon A. Leipsic

Erica Maffei, Gianluca Pontone, Gilbert L. Raff, Sanghoon Shin, Yong Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Sang Eun Lee, Daniel S. Berman, Renu Virmani, Habib Samady, Peter H. Stone, Jagat Narula, Jeroen J. Bax, Leslee J. Shaw, James K. Min^*, Hyuk Jae Chang

^*Autor correspondente para este trabalho

Resultado de pesquisa › revisão de pares

49 Citações (Scopus)

Resumo

Background and aims: Different methodologies to report whole-heart atherosclerotic plaque on coronary computed tomography angiography (CCTA) have been utilized. We examined which of the three commonly used plaque burden definitions was least affected by differences in body surface area (BSA) and sex. Methods: The PARADIGM study includes symptomatic patients with suspected coronary atherosclerosis who underwent serial CCTA >2 years apart. Coronary lumen, vessel, and plaque were quantified from the coronary tree on a 0.5 mm cross-sectional basis by a core-lab, and summed to per-patient. Three quantitative methods of plaque burden were employed: (1) total plaque volume (PV) in mm³, (2) percent atheroma volume (PAV) in % [which equaled: PV/vessel volume * 100%], and (3) normalized total atheroma volume (TAV_norm) in mm³ [which equaled: PV/vessel length * mean population vessel length]. Only data from the baseline CCTA were used. PV, PAV, and TAV_norm were compared between patients in the top quartile of BSA vs the remaining, and between sexes. Associations between vessel volume, BSA, and the three plaque burden methodologies were assessed. Results: The study population comprised 1479 patients (age 60.7 ± 9.3 years, 58.4% male) who underwent CCTA. A total of 17,649 coronary artery segments were evaluated with a median of 12 (IQR 11–13) segments per-patient (from a 16-segment coronary tree). Patients with a large BSA (top quartile), compared with the remaining patients, had a larger PV and TAV_norm, but similar PAV. The relation between larger BSA and larger absolute plaque volume (PV and TAV_norm) was mediated by the coronary vessel volume. Independent from the atherosclerotic cardiovascular disease risk (ASCVD) score, vessel volume correlated with PV (P < 0.001), and TAV_norm (P = 0.003), but not with PAV (P = 0.201). The three plaque burden methods were equally affected by sex. Conclusions: PAV was less affected by patient's body surface area then PV and TAV_norm and may be the preferred method to report coronary atherosclerotic burden.

Idioma original	English
Páginas (de-até)	400-406
Número de páginas	7
Revista	Journal of Cardiovascular Computed Tomography
Volume	14
Número de emissão	5
DOIs	https://doi.org/10.1016/j.jcct.2020.01.012
Estado da publicação	Publicado - 1 set. 2020
Publicado externamente	Sim

ODS da ONU

Este resultado contribui para o(s) seguinte(s) Objetivo(s) de Desenvolvimento Sustentável

ODS 3 Boa saúde e bem-estar

Acesso ao documento

10.1016/j.jcct.2020.01.012

Outros arquivos e links

Link to publication in Scopus

Citação

Rosendael, A. R. V., Lin, F. Y., Ma, X., Hoogen, I. J. V. D., Gianni, U., Hussein, O. A., Al'Aref, S. J., Peña, J. M., Andreini, D., Al-Mallah, M. H., Budoff, M. J., Cademartiri, F., Chinnaiyan, K., Choi, J. H., Conte, E., Marques, H., Gonçalves, P. D. A., Gottlieb, I., Hadamitzky, M., ... Chang, H. J. (2020). Percent atheroma volume: optimal variable to report whole-heart atherosclerotic plaque burden with coronary CTA, the PARADIGM study. Journal of Cardiovascular Computed Tomography, 14(5), 400-406. https://doi.org/10.1016/j.jcct.2020.01.012

@article{617465622ed44216bce1945a693a935f,

title = "Percent atheroma volume: optimal variable to report whole-heart atherosclerotic plaque burden with coronary CTA, the PARADIGM study",

abstract = "Background and aims: Different methodologies to report whole-heart atherosclerotic plaque on coronary computed tomography angiography (CCTA) have been utilized. We examined which of the three commonly used plaque burden definitions was least affected by differences in body surface area (BSA) and sex. Methods: The PARADIGM study includes symptomatic patients with suspected coronary atherosclerosis who underwent serial CCTA >2 years apart. Coronary lumen, vessel, and plaque were quantified from the coronary tree on a 0.5 mm cross-sectional basis by a core-lab, and summed to per-patient. Three quantitative methods of plaque burden were employed: (1) total plaque volume (PV) in mm3, (2) percent atheroma volume (PAV) in \% [which equaled: PV/vessel volume * 100\%], and (3) normalized total atheroma volume (TAVnorm) in mm3 [which equaled: PV/vessel length * mean population vessel length]. Only data from the baseline CCTA were used. PV, PAV, and TAVnorm were compared between patients in the top quartile of BSA vs the remaining, and between sexes. Associations between vessel volume, BSA, and the three plaque burden methodologies were assessed. Results: The study population comprised 1479 patients (age 60.7 ± 9.3 years, 58.4\% male) who underwent CCTA. A total of 17,649 coronary artery segments were evaluated with a median of 12 (IQR 11–13) segments per-patient (from a 16-segment coronary tree). Patients with a large BSA (top quartile), compared with the remaining patients, had a larger PV and TAVnorm, but similar PAV. The relation between larger BSA and larger absolute plaque volume (PV and TAVnorm) was mediated by the coronary vessel volume. Independent from the atherosclerotic cardiovascular disease risk (ASCVD) score, vessel volume correlated with PV (P < 0.001), and TAVnorm (P = 0.003), but not with PAV (P = 0.201). The three plaque burden methods were equally affected by sex. Conclusions: PAV was less affected by patient's body surface area then PV and TAVnorm and may be the preferred method to report coronary atherosclerotic burden.",

keywords = "Atherosclerosis, Coronary CTA, Imaging, Percent atheroma volume",

author = "Rosendael, \{Alexander R. van\} and Lin, \{Fay Y.\} and Xiaoyue Ma and Hoogen, \{Inge J. van den\} and Umberto Gianni and Hussein, \{Omar Al\} and Al'Aref, \{Subhi J.\} and Pe{\~n}a, \{Jessica M.\} and Daniele Andreini and Al-Mallah, \{Mouaz H.\} and Budoff, \{Matthew J.\} and Filippo Cademartiri and Kavitha Chinnaiyan and Choi, \{Jung Hyun\} and Edoardo Conte and Hugo Marques and Gon{\c c}alves, \{Pedro de Ara{\'u}jo\} and Ilan Gottlieb and Martin Hadamitzky and Leipsic, \{Jonathon A.\} and Erica Maffei and Gianluca Pontone and Raff, \{Gilbert L.\} and Sanghoon Shin and Kim, \{Yong Jin\} and Lee, \{Byoung Kwon\} and Chun, \{Eun Ju\} and Sung, \{Ji Min\} and Lee, \{Sang Eun\} and Berman, \{Daniel S.\} and Renu Virmani and Habib Samady and Stone, \{Peter H.\} and Jagat Narula and Bax, \{Jeroen J.\} and Shaw, \{Leslee J.\} and Min, \{James K.\} and Chang, \{Hyuk Jae\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = sep,

day = "1",

doi = "10.1016/j.jcct.2020.01.012",

language = "English",

volume = "14",

pages = "400--406",

journal = "Journal of Cardiovascular Computed Tomography",

issn = "1934-5925",

publisher = "Elsevier Inc.",

number = "5",

}

Rosendael, ARV, Lin, FY, Ma, X, Hoogen, IJVD, Gianni, U, Hussein, OA, Al'Aref, SJ, Peña, JM, Andreini, D, Al-Mallah, MH, Budoff, MJ, Cademartiri, F, Chinnaiyan, K, Choi, JH, Conte, E, Marques, H, Gonçalves, PDA, Gottlieb, I, Hadamitzky, M, Leipsic, JA, Maffei, E, Pontone, G, Raff, GL, Shin, S, Kim, YJ, Lee, BK, Chun, EJ, Sung, JM, Lee, SE, Berman, DS, Virmani, R, Samady, H, Stone, PH, Narula, J, Bax, JJ, Shaw, LJ, Min, JK & Chang, HJ 2020, 'Percent atheroma volume: optimal variable to report whole-heart atherosclerotic plaque burden with coronary CTA, the PARADIGM study', Journal of Cardiovascular Computed Tomography, vol. 14, n.º 5, pp. 400-406. https://doi.org/10.1016/j.jcct.2020.01.012

TY - JOUR

T1 - Percent atheroma volume

T2 - optimal variable to report whole-heart atherosclerotic plaque burden with coronary CTA, the PARADIGM study

AU - Rosendael, Alexander R. van

AU - Lin, Fay Y.

AU - Ma, Xiaoyue

AU - Hoogen, Inge J. van den

AU - Gianni, Umberto

AU - Hussein, Omar Al

AU - Al'Aref, Subhi J.

AU - Peña, Jessica M.

AU - Andreini, Daniele

AU - Al-Mallah, Mouaz H.

AU - Budoff, Matthew J.

AU - Cademartiri, Filippo

AU - Chinnaiyan, Kavitha

AU - Choi, Jung Hyun

AU - Conte, Edoardo

AU - Marques, Hugo

AU - Gonçalves, Pedro de Araújo

AU - Gottlieb, Ilan

AU - Hadamitzky, Martin

AU - Leipsic, Jonathon A.

AU - Maffei, Erica

AU - Pontone, Gianluca

AU - Raff, Gilbert L.

AU - Shin, Sanghoon

AU - Kim, Yong Jin

AU - Lee, Byoung Kwon

AU - Chun, Eun Ju

AU - Sung, Ji Min

AU - Lee, Sang Eun

AU - Berman, Daniel S.

AU - Virmani, Renu

AU - Samady, Habib

AU - Stone, Peter H.

AU - Narula, Jagat

AU - Bax, Jeroen J.

AU - Shaw, Leslee J.

AU - Min, James K.

AU - Chang, Hyuk Jae

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Background and aims: Different methodologies to report whole-heart atherosclerotic plaque on coronary computed tomography angiography (CCTA) have been utilized. We examined which of the three commonly used plaque burden definitions was least affected by differences in body surface area (BSA) and sex. Methods: The PARADIGM study includes symptomatic patients with suspected coronary atherosclerosis who underwent serial CCTA >2 years apart. Coronary lumen, vessel, and plaque were quantified from the coronary tree on a 0.5 mm cross-sectional basis by a core-lab, and summed to per-patient. Three quantitative methods of plaque burden were employed: (1) total plaque volume (PV) in mm3, (2) percent atheroma volume (PAV) in % [which equaled: PV/vessel volume * 100%], and (3) normalized total atheroma volume (TAVnorm) in mm3 [which equaled: PV/vessel length * mean population vessel length]. Only data from the baseline CCTA were used. PV, PAV, and TAVnorm were compared between patients in the top quartile of BSA vs the remaining, and between sexes. Associations between vessel volume, BSA, and the three plaque burden methodologies were assessed. Results: The study population comprised 1479 patients (age 60.7 ± 9.3 years, 58.4% male) who underwent CCTA. A total of 17,649 coronary artery segments were evaluated with a median of 12 (IQR 11–13) segments per-patient (from a 16-segment coronary tree). Patients with a large BSA (top quartile), compared with the remaining patients, had a larger PV and TAVnorm, but similar PAV. The relation between larger BSA and larger absolute plaque volume (PV and TAVnorm) was mediated by the coronary vessel volume. Independent from the atherosclerotic cardiovascular disease risk (ASCVD) score, vessel volume correlated with PV (P < 0.001), and TAVnorm (P = 0.003), but not with PAV (P = 0.201). The three plaque burden methods were equally affected by sex. Conclusions: PAV was less affected by patient's body surface area then PV and TAVnorm and may be the preferred method to report coronary atherosclerotic burden.

AB - Background and aims: Different methodologies to report whole-heart atherosclerotic plaque on coronary computed tomography angiography (CCTA) have been utilized. We examined which of the three commonly used plaque burden definitions was least affected by differences in body surface area (BSA) and sex. Methods: The PARADIGM study includes symptomatic patients with suspected coronary atherosclerosis who underwent serial CCTA >2 years apart. Coronary lumen, vessel, and plaque were quantified from the coronary tree on a 0.5 mm cross-sectional basis by a core-lab, and summed to per-patient. Three quantitative methods of plaque burden were employed: (1) total plaque volume (PV) in mm3, (2) percent atheroma volume (PAV) in % [which equaled: PV/vessel volume * 100%], and (3) normalized total atheroma volume (TAVnorm) in mm3 [which equaled: PV/vessel length * mean population vessel length]. Only data from the baseline CCTA were used. PV, PAV, and TAVnorm were compared between patients in the top quartile of BSA vs the remaining, and between sexes. Associations between vessel volume, BSA, and the three plaque burden methodologies were assessed. Results: The study population comprised 1479 patients (age 60.7 ± 9.3 years, 58.4% male) who underwent CCTA. A total of 17,649 coronary artery segments were evaluated with a median of 12 (IQR 11–13) segments per-patient (from a 16-segment coronary tree). Patients with a large BSA (top quartile), compared with the remaining patients, had a larger PV and TAVnorm, but similar PAV. The relation between larger BSA and larger absolute plaque volume (PV and TAVnorm) was mediated by the coronary vessel volume. Independent from the atherosclerotic cardiovascular disease risk (ASCVD) score, vessel volume correlated with PV (P < 0.001), and TAVnorm (P = 0.003), but not with PAV (P = 0.201). The three plaque burden methods were equally affected by sex. Conclusions: PAV was less affected by patient's body surface area then PV and TAVnorm and may be the preferred method to report coronary atherosclerotic burden.

KW - Atherosclerosis

KW - Coronary CTA

KW - Imaging

KW - Percent atheroma volume

UR - https://www.scopus.com/pages/publications/85079527446

U2 - 10.1016/j.jcct.2020.01.012

DO - 10.1016/j.jcct.2020.01.012

M3 - Article

C2 - 32063545

AN - SCOPUS:85079527446

SN - 1934-5925

VL - 14

SP - 400

EP - 406

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

IS - 5

ER -

Percent atheroma volume: optimal variable to report whole-heart atherosclerotic plaque burden with coronary CTA, the PARADIGM study

Resumo

ODS da ONU

Acesso ao documento

Outros arquivos e links

Impressão digital

Citação