Phthalic anhydride esterified chicha gum: characterization and antibacterial activity

Solranny Carla Cavalcante Costa Silva, Elton Marks Araujo Braz, Carla Adriana Rodrigues Sousa Brito, Michel Muálem Moraes Alves, Fernando Aécio Amorim Carvalho, Humberto Medeiros Barreto, Ana Leite Oliveira, Durcilene Alves Silva, Edson C. Silva-Filho*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

16 Citações (Scopus)

Resumo

The objective of this research was to modify chicha gum with phthalic anhydride to obtain a new biologically active material. The chemical modification of the gum structure was proven through FTIR, elemental analysis, XRD, TG, and DSC. The derived materials demonstrated excellent inhibitory effect against P. aeruginosa and K. pneumoniae species (rating 100% inhibition) and could also inhibit Escherichia coli growth. The best antimicrobial activity observed for the derivatives suggests that chicha gum hydrophobization due to the addition of phthalic groups improved the interaction of these derivatives with bacterial cell wall components. On the other hand, the derivatives increased CC50 in macrophages but did not present acute toxicity or hemolytic activity, indicating that they are promising for use in prophylaxis or treatment of infections caused by Gram-negative bacteria.
Idioma originalEnglish
Número do artigo117077
Páginas (de-até)1-11
Número de páginas11
RevistaCarbohydrate Polymers
Volume251
DOIs
Estado da publicaçãoPublicado - 1 jan. 2021

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