Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications

P. Coimbra; P. Ferreira; H. C. de Sousa; P. Batista; M. A. Rodrigues; I. J. Correia; M. H. Gil

doi:10.1016/j.ijbiomac.2010.10.006

Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications

P. Coimbra^*
, P. Ferreira
, H. C. de Sousa
, P. Batista
, M. A. Rodrigues
, I. J. Correia
, M. H. Gil

^*Autor correspondente para este trabalho

Centro de Investigação Interdisciplinar em Saúde (CIIS)

Resultado de pesquisa › revisão de pares

198 Citações (Scopus)

Resumo

In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic.

Idioma original	English
Páginas (de-até)	112-118
Número de páginas	7
Revista	International Journal of Biological Macromolecules
Volume	48
Número de emissão	1
DOIs	https://doi.org/10.1016/j.ijbiomac.2010.10.006
Estado da publicação	Publicado - 1 jan. 2011

Acesso ao documento

10.1016/j.ijbiomac.2010.10.006

Outros arquivos e links

https://www.scopus.com/pages/publications/78650252426

Citação

Coimbra, P., Ferreira, P., de Sousa, H. C., Batista, P., Rodrigues, M. A., Correia, I. J., & Gil, M. H. (2011). Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications. International Journal of Biological Macromolecules, 48(1), 112-118. https://doi.org/10.1016/j.ijbiomac.2010.10.006

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abstract = "In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic.",

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Coimbra, P, Ferreira, P, de Sousa, HC, Batista, P, Rodrigues, MA, Correia, IJ & Gil, MH 2011, 'Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications', International Journal of Biological Macromolecules, vol. 48, n.º 1, pp. 112-118. https://doi.org/10.1016/j.ijbiomac.2010.10.006

TY - JOUR

T1 - Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications

AU - Coimbra, P.

AU - Ferreira, P.

AU - de Sousa, H. C.

AU - Batista, P.

AU - Rodrigues, M. A.

AU - Correia, I. J.

AU - Gil, M. H.

PY - 2011/1/1

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N2 - In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic.

AB - In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic.

KW - Cytotoxicity

KW - Osteoblasts

KW - Polyelectrolyte complexes

KW - Polymeric scaffold

UR - https://www.scopus.com/pages/publications/78650252426

U2 - 10.1016/j.ijbiomac.2010.10.006

DO - 10.1016/j.ijbiomac.2010.10.006

M3 - Article

AN - SCOPUS:78650252426

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VL - 48

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JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

IS - 1

ER -

Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications

Resumo

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