Prevention and treatment of diabetic retinopathy by natural antioxidant containing in chitosan-based nanomedicines

S. B. da Silva, D. Carvalho, M. Pintado, B. Sarmento

Resultado de pesquisarevisão de pares

7 Transferências (Pure)

Resumo

Oxidative processes are critical factors in ocular conditions that may lead to pathologies such as Diabetic Retinopahty due to structural and functional modification of the tissues, apoptosis of capillary cells and retinal microvascular changes, making the loss of vision inevitable. Application of antioxidants may reduce apoptosis and restores partially functional tissues. Considering the multiple benefits of antioxidants in DR and that conjunctival drug permeability improvement is one of the major challenges in ocular drug delivery, the major topic of this work is to study the absorption capacity and consequent bioavailability of natural antioxidants incorporated in chitosan-based nanoparticles to prevent and treat DR. In this regards, it is proposed to characterize, quantify and compare the antioxidant potential of Salvia sp. and Satureja montana extracts and their main pure antioxidants: rutin, caffeic and clorogenic acid. Then, antioxidant compounds are encapsulated into different chitosan-based nanoparticles, nanoparticles and release profile characterized and ocular permeation evaluated using in vitro cell models. Finally, the effect of antioxidant nanomedicines across human ocular is evaluated in diabetic animal after topical administration in vivo.
Idioma originalEnglish
Páginas25-25
Número de páginas1
Estado da publicaçãoPublicado - mar. 2010
Evento1ª Workshop anual BioPlant - Porto
Duração: 29 mar. 201030 mar. 2010

Workshop

Workshop1ª Workshop anual BioPlant
País/TerritórioPortugal
CidadePorto
Período29/03/1030/03/10

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