TY - JOUR
T1 - Recent advances in silk sericin/calcium phosphate biomaterials
AU - Veiga, Anabela
AU - Castro, Filipa
AU - Rocha, Fernando
AU - Oliveira, Ana L.
N1 - Funding Information:
This work was financially supported by: Base Funding – UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE – funded by national funds through the FCT/MCTES (PIDDAC). The authors also acknowledge Portuguese National Funds from FCT—Fundação para a Ciência e a Tecnologia through project UID/Multi/04044/2019. This work was supported by project Biotherapies-Bioengineered Therapies for Infectious Diseases and Tissue Regeneration and Interreg V-A POCTEP Programme through FEDER funds from the European Union [0245_IBEROS_1_E] C. A.
Funding Information:
The authors also extend their deep appreciation to Department of Chemical Engineering at Faculty of Engineering of the University of Porto, and Centre for Biotechnology and Fine Chemistry at School of Biotechnology of the Portuguese Catholic University. Funding. This work was financially supported by: Base Funding ? UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy ? LEPABE ? funded by national funds through the FCT/MCTES (PIDDAC). The authors also acknowledge Portuguese National Funds from FCT?Funda??o para a Ci?ncia e a Tecnologia through project UID/Multi/04044/2019. This work was supported by project Biotherapies-Bioengineered Therapies for Infectious Diseases and Tissue Regeneration and Interreg V-A POCTEP Programme through FEDER funds from the European Union [0245_IBEROS_1_E] C. A.
Publisher Copyright:
© Copyright © 2020 Veiga, Castro, Rocha and Oliveira.
PY - 2020/2/18
Y1 - 2020/2/18
N2 - Calcium phosphates (CaPs) have been widely used in the field of biomedical engineering as bone graft substitutes or as carriers for drug delivery applications. Recent developments have focused on combining CaPs with proteins to obtain functional biomaterials that accommodate a broader spectrum of functional requirements. Silk sericin was considered an unutilized protein by-product from the textile industry, generating tons of residues every year. However, much effort has been dedicated to its recovery after being associated with numerous biological properties such as antioxidant, antibacterial, anti-coagulation and regenerative activities. In the past years, sericin has also demonstrated to be suitable as a template for CaP mineralization. The present review focuses on the recent developments for the production of sericin/CaP composites, exploring their potential applications in bioengineering and opening new avenues in other research fields such as in the cosmetic, food and environmental sectors. In addition, this paper can also be useful as a guideline to design future research based on sericin/CaP biomaterials.
AB - Calcium phosphates (CaPs) have been widely used in the field of biomedical engineering as bone graft substitutes or as carriers for drug delivery applications. Recent developments have focused on combining CaPs with proteins to obtain functional biomaterials that accommodate a broader spectrum of functional requirements. Silk sericin was considered an unutilized protein by-product from the textile industry, generating tons of residues every year. However, much effort has been dedicated to its recovery after being associated with numerous biological properties such as antioxidant, antibacterial, anti-coagulation and regenerative activities. In the past years, sericin has also demonstrated to be suitable as a template for CaP mineralization. The present review focuses on the recent developments for the production of sericin/CaP composites, exploring their potential applications in bioengineering and opening new avenues in other research fields such as in the cosmetic, food and environmental sectors. In addition, this paper can also be useful as a guideline to design future research based on sericin/CaP biomaterials.
KW - Biomaterials
KW - Bone tissue engineering (bone-TE)
KW - Calcium phosphates (CaPs)
KW - Drug delivery
KW - Hydroxyapatite (HAp)
KW - Sericin
UR - https://www.scopus.com/pages/publications/85080948025
U2 - 10.3389/fmats.2020.00024
DO - 10.3389/fmats.2020.00024
M3 - Review article
AN - SCOPUS:85080948025
SN - 2296-8016
VL - 7
SP - 1
EP - 14
JO - Frontiers in Materials
JF - Frontiers in Materials
M1 - 24
ER -