SalivaPrint as a non-invasive diagnostic tool

Eduardo Esteves*, Igor Cruz, Ana Cristina Esteves, Marlene Barros, Nuno Rosa

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

1 Citação (Scopus)
1 Transferências (Pure)

Resumo

Currently, the molecular diagnosis is based on the quantification of RNA, proteins and metabolites because they present changes in their quantity related to clinical situations. The same molecules are not generally suitable for early diagnosis or to follow clinical evolution, making necessary strategies to evaluate the complete molecular scenario. There are already experimental strategies that allow the determination of total protein profiles from saliva samples (the SalivaPrint). The goal of this work is to identify a profile of saliva proteins (similar to a fingerprint) and, using computational methods, identify how this profiles changes with age and gender. So far it has been possible to collect 79 samples as well as the metadata associated with each sample using an electronic questionnaire developed by us. A total protein profile was obtained and their association with gender was verified using statistical methods. Currently we are developing the Python scripts for automatic data acquiring and normalization. Total protein profiles annotation on a database (SalivaPrintDB) and their integration with the factors that affects them using machine learning strategies can empower the use of the approach proposed on this work as a tool for monitoring the individual's health status.
Idioma originalEnglish
Título da publicação do anfitriãoHEALTHINF 2020 - 13th International Conference on Health Informatics, Proceedings; Part of 13th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2020
EditoresFederico Cabitza, Ana Fred, Hugo Gamboa
EditoraSciTePress
Páginas677-682
Número de páginas6
ISBN (eletrónico)9789897583988
ISBN (impresso)9789897583988
DOIs
Estado da publicaçãoPublished - 1 jan 2020
Evento13th International Conference on Health Informatics, HEALTHINF 2020 - Part of 13th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2020 - Valletta
Duração: 24 fev 202026 fev 2020

Série de publicação

NomeHEALTHINF 2020 - 13th International Conference on Health Informatics, Proceedings; Part of 13th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2020

Conferência

Conferência13th International Conference on Health Informatics, HEALTHINF 2020 - Part of 13th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2020
País/TerritórioMalta
CidadeValletta
Período24/02/2026/02/20

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