Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias

António Morais*, Marília Beltrão, Oksana Sokhatska, Diogo Costa, Natalia Melo, Patricia Mota, Agostinho Marques, Luís Delgado

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

52 Citações (Scopus)

Resumo

Introduction Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) has important therapeutic and prognostic implications and would be greatly aided by reliable diagnostic biomarkers as IPF has sometimes overlapping features with other interstitial lung diseases (ILD). Objectives To explore the value of serum metalloproteinases (MMP) 1 and 7 levels in the differential diagnosis of IPF with other ILD. Methods MMP-1/7 serum levels were measured using Luminex xMAP technology in 139 patients- 47 IPF, 36 non-IPF Usual Interstitial Pneumonia (UIP), 14 idiopathic Nonspecific Interstitial Pneumonia (iNSIP), 29 secondary NSIP (secNSIP), 13 stage IV sarcoidosis- and 20 healthy controls, and compared using the Mann-Whitney U test. Results MMP-1 was significantly higher in IPF than non-IPF UIP (P =.042) and sarcoidosis (P =.027). MMP-7 was significantly higher in IPF than controls (P <.001), non-IPF UIP (P =.003), secNSIP (P <.001), and sarcoidosis (P <.001). The Area Under the Curve for IPF versus other ILD was 0.63 (95%CI, 0.53-0.73) for MMP-1, 0.73 (95%CI, 0.65-0.81) for MMP-7, and 0.74 (95%CI, 0.66-0.82) for MMP-1/MMP-7 combined. Sensitivity and specificity for MMP-7 cutoff = 3.91 ng/mL was 72.3% and 66.3%, respectively, Positive Predictive Values = 52.3% and Negative Predictive Values = 82.4%. Conclusions MMP-1 and particularly MMP-7 serum levels were significantly higher in IPF than in non-IPF UIP, the main entity in differential diagnosis. The value of these biomarkers as additional tools in a multidisciplinary approach to IPF diagnosis needs to be considered and further explored.

Idioma originalEnglish
Páginas (de-até)1063-1068
Número de páginas6
RevistaRespiratory Medicine
Volume109
Número de emissão8
DOIs
Estado da publicaçãoPublicado - 1 ago. 2015
Publicado externamenteSim

Impressão digital

Mergulhe nos tópicos de investigação de “Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias“. Em conjunto formam uma impressão digital única.

Citação