Silk fibroin/nano-CaP bilayered scaffolds for osteochondral tissue engineering

Le Ping Yan, Joaquim M. Oliveira, Ana L. Oliveira, Rui L. Reis*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

20 Citações (Scopus)

Resumo

In this study, bilayered silk and silk/nano-CaP scaffolds were developed for osteochondral (OC) tissue engineering. Aqueous silk solution (16 wt.%) was used for preparation of the cartilage-like layer and, for generation of the silk/nano-CaP suspension and the bottom layer (CaP/Silk: 16 wt.%). The scaffolds were formed by using salt-leaching/lyophilization approach. The scanning electron microscopy revealed that the both layers presented porous structure and integrated well. Micro-computed tomography images confirmed that the CaP phase was only retained in the silk/nano-CaP layer. The hydration degree and mechanical properties of the bilayered scaffold were comparable to the ones of each single layer. The apatite crystal formation was limited to the silk/nano-CaP layer, when soaking the scaffold in a simulated body fluid solution, which is a must for the application of the developed scaffolds in OC tissue engineering.
Idioma originalEnglish
Título da publicação do anfitriãoBioceramics 25
EditoraTrans Tech Publications Ltd
Páginas245-248
Número de páginas4
ISBN (impresso)9783037858998
DOIs
Estado da publicaçãoPublished - 2014
Evento25th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2013 - Bucharest
Duração: 7 nov 201310 nov 2013

Série de publicação

NomeKey Engineering Materials
Volume587
ISSN (impresso)1013-9826
ISSN (eletrónico)1662-9795

Conferência

Conferência25th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2013
País/TerritórioRomania
CidadeBucharest
Período7/11/1310/11/13

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