Study of bone repair in rat dental socket after implantation of porous granules of beta-tricalcium phosphate (β-TCP) and magnesiumsubstituted beta-tricalcium phosphate (β-TCMP)

Debora Helena Yassuda-Mattos*, Neusa Motta Freitas Costa, Débora Tavares, Gustavo Vicentis de Oliveira Fernandes, Adriana Therezinha Alves, José Mauro Granjeiro, Glória Dulce de Almeida Soares

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

2 Citações (Scopus)

Resumo

Porous granules were obtained through a route using a mixture of calcium phosphate powder with sodium alginate solution. The sintered β-TCP and β-TCMP granules with diameters ranging from 250 μm to 500 μm were implanted into dental alveoli of 30 rats (Rattus norvegicus). The animals were divided in three groups: group I (control, no treatment), group II (β-TCP) and group III (β-TCMP); the sacrifices occurred at 7 and 21 days (n=5/group/period). Histological and histomorphometric analysis were performed to observe and measure connective tissue, bone neoformation and biomaterial areas. Most animals showed acute inflammatory response with many neutrophil granulocytes and foreign body giant multinucleated cells associated to both biomaterials, at 7 and 21 days. The utilization of sodium alginate as additive in the porous granules might explain these results. Fourier-transformed infrared spectroscopy (FTIR) pointed out residue in the granules surface that could exacerbate the inflammatory response. Additional studies are in course to confirm such hypothesis.
Idioma originalEnglish
Título da publicação do anfitriãoBioceramics 23
EditoraTrans Tech Publications Ltd
Páginas263-268
Número de páginas6
ISBN (impresso)9783037852552
DOIs
Estado da publicaçãoPublicado - 2012
Publicado externamenteSim
Evento23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011 - Istanbul
Duração: 6 nov 20119 nov 2011

Série de publicação

NomeKey Engineering Materials
Volume493-494
ISSN (impresso)1013-9826
ISSN (eletrónico)1662-9795

Conferência

Conferência23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011
País/TerritórioTurkey
CidadeIstanbul
Período6/11/119/11/11

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