Sustainable natural gums for industrial application: physiochemical and texturometric evaluation

Susana Raquel dos Santos Ferreira, Martha Vitória Norberto Mesquita, Laisa Lis Fontinele de Sá, Naiane Carvalho Nogueira, Márcia dos Santos Rizzo, Edson Cavalcanti Silva-Filho, Marcília Pinheiro da Costa*, Alessandra Braga Ribeiro

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

13 Citações (Scopus)

Resumo

In this study, the cashew gum (Anacardium occidentale Linn) (GCa) and chicha gum (Sterculia striata) (GCh) were characterized and used in the development of tables and hydrogels. For this purpose, the gums were initially characterized by XRD, FTIR, TG, and DSC, and flow property. The tablets obtained were evaluated for hardness, swelling, and mucoadhesiveness, while the hydrogels developed were assessed by texturometric assays. The physicochemical analysis demonstrated that the GCa and GCh gums present microcrystalline and amorphous structures, respectively. Both were classified as fine powders and presented proper flowability and compressibility to the development of tables. The tablets containing GCa and GCh presented mucoadhesion strength of 2.10 ± 0.31 N and 1.72 ± 0.30 N, respectively. Both tablets exhibited similar mucoadhesion behavior to the polymers conventionally used for this purpose, such as the carbomers. However, there was an evident difference in the swelling process, in which the GCa table presented high erosion and low swelling, while the GCh tables presented a crescent and linear swelling behavior and no erosion process in the observed time. GCh hydrogel was the most easily obtained and presented the best thick consistency and adhesion compatible with topical formulations. Thus, based on the results found, we can conclude that both natural polymers are promising excipients in the development of adhesive and control drug delivery formulations.
Idioma originalEnglish
Número do artigo101306
RevistaJournal of Drug Delivery Science and Technology
Volume54
DOIs
Estado da publicaçãoPublicado - dez. 2019
Publicado externamenteSim

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