TY - JOUR
T1 - Synthesis and photodynamic effects of new porphyrin/4-oxoquinoline derivatives in the inactivation of S. aureus
AU - Sagrillo, Fernanda Savacini
AU - Dias, Cristina
AU - Gomes, Ana T.P.C.
AU - Faustino, Maria A.F.
AU - Almeida, Adelaide
AU - Gonçalves De Souza, Alan
AU - Costa, Amanda Rodrigues Pinto
AU - Boechat, Fernanda Da Costa Santos
AU - Bastos Vieira De Souza, Maria Cecília
AU - Neves, Maria G.P.M.S.
AU - Cavaleiro, José A.S.
N1 - Funding Information:
Thanks are due to the University of Aveiro, to FCT/MEC for the financial support to the QOPNA Research Unit (FCT UID/QUI/00062/2019) and the Centre for Environmental and Marine Studies (CESAM) Unit (UID/AMB/50017/2019) and the cofunding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020, and also the Portuguese NMR Network is acknowledged. Thanks are also due to Universidade Federal Fluminence, FAPERJ, CNPQ, CAPES (finance Code 001), and UFF for financial support and fellowships. Fernanda Savacini Sagrillo thanks CAPES for granting the scholarship for a sandwich doctorate (PDSE) at the University of Aveiro. C. J. Dias also thanks FCT for her research fellowship (BI/UI51/7965/2017).
Funding Information:
Thanks are due to the University of Aveiro, to FCT/MEC for the financial support to the QOPNA Research Unit (FCT UID/QUI/ 00062/2019) and the Centre for Environmental and Marine Studies (CESAM) Unit (UID/AMB/50017/2019) and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020, and also the Portuguese NMR Network is acknowledged. Thanks are also due to Universidade Federal Fluminence, FAPERJ, CNPQ, CAPES (finance Code 001), and UFF for financial support and fellowships. Fernanda Savacini Sagrillo thanks CAPES for granting the scholarship for a sandwich doctorate (PDSE) at the University of Aveiro. C. J. Dias also thanks FCT for her research fellowship (BI/UI51/7965/2017).
Publisher Copyright:
This journal is © The Royal Society of Chemistry and Owner Societies.
PY - 2019
Y1 - 2019
N2 - New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a β-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a-e. Singlet oxygen studies have demonstrated that all the porphyrin/4-oxoquinoline conjugates 9a-e were capable of producing cytotoxic species and found to be excellent photosensitizing agents in the inactivation of S. aureus by the antimicrobial photodynamic therapy (aPDT) protocol.
AB - New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a β-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a-e. Singlet oxygen studies have demonstrated that all the porphyrin/4-oxoquinoline conjugates 9a-e were capable of producing cytotoxic species and found to be excellent photosensitizing agents in the inactivation of S. aureus by the antimicrobial photodynamic therapy (aPDT) protocol.
UR - https://www.scopus.com/pages/publications/85070560526
U2 - 10.1039/c9pp00102f
DO - 10.1039/c9pp00102f
M3 - Article
C2 - 31328761
AN - SCOPUS:85070560526
SN - 1474-905X
VL - 18
SP - 1910
EP - 1922
JO - Photochemical and Photobiological Sciences
JF - Photochemical and Photobiological Sciences
IS - 8
ER -