@article{365c1f4801da4d36830544015a7843e6,
title = "Synthesis, characterization and photodynamic activity against bladder cancer cells of novel triazole-porphyrin derivatives",
abstract = "Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.",
keywords = "Human bladder cancer cells, Human retinal pigment epithelial cells, Photodynamic therapy, Polyvinylpyrrolidone, Porphyrin, Triazole",
author = "Gomes, {Ana T.P.C.} and Rosa Fernandes and Ribeiro, {Carlos F.} and Tom{\'e}, {Jo{\~a}o P.C.} and Neves, {Maria G.P.M.S.} and {da Silva}, {Fernando de C.} and Ferreira, {V{\'i}tor F.} and Cavaleiro, {Jos{\'e} A.S.}",
note = "Funding Information: Funding: The authors are grateful to University of Aveiro and FCT/MCT for the financial support for QOPNA research Unit (FCT UID/QUI/00062/2019) and LAQV-REQUIMTE (UIDB/50006/2020) through national funds. Thanks are also due to FCT/MCT for the financial support of iCBR and CIBB units (TDC/QEQQOR/1273/2012; UID/NEU/04539/2019 FCT UID/QUI/00062/2013) and CQE unit (UIDB/00100/2020), COMPETE-FEDER (POCI-01-0145-FEDER-007440) and Centro 2020 Regional Operational Programme: HEALTHYAGING 2020 (CENTRO-01-0145-FEDER-000012) for funding. Ana Gomes also thanks FCT for the post-doctoral grant (SFRH/BPD/79521/2011). Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",
year = "2020",
doi = "10.3390/molecules25071607",
language = "English",
volume = "25",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "7",
}
