Synthesis, characterization and photodynamic activity against bladder cancer cells of novel triazole-porphyrin derivatives

Ana T.P.C. Gomes*, Rosa Fernandes, Carlos F. Ribeiro, João P.C. Tomé, Maria G.P.M.S. Neves, Fernando de C. da Silva, Vítor F. Ferreira, José A.S. Cavaleiro

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

8 Citações (Scopus)

Resumo

Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.
Idioma originalEnglish
Número do artigo1607
RevistaMolecules
Volume25
Número de emissão7
DOIs
Estado da publicaçãoPublished - 2020
Publicado externamenteSim

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