The complex interplay between antibiotic resistance and pharmaceutical and personal care products in the environment

Célia M. Manaia*, Diana S. Aga, Eddie Cytryn, William H. Gaze, David W. Graham, Jianhua Guo, Anne F. C. Leonard, Liguan Li, Aimee K. Murray, Olga C. Nunes, Sara Rodriguez-Mozaz, Edward Topp, Tong Zhang

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

16 Citações (Scopus)

Resumo

Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are important environmental contaminants. Nonetheless, what drives the evolution, spread, and transmission of antibiotic resistance dissemination is still poorly understood. The abundance of ARB and ARGs is often elevated in human-impacted areas, especially in environments receiving fecal wastes, or in the presence of complex mixtures of chemical contaminants, such as pharmaceuticals and personal care products. Self-replication, mutation, horizontal gene transfer, and adaptation to different environmental conditions contribute to the persistence and proliferation of ARB in habitats under strong anthropogenic influence. Our review discusses the interplay between chemical contaminants and ARB and their respective genes, specifically in reference to co-occurrence, potential biostimulation, and selective pressure effects, and gives an overview of mitigation by existing man-made and natural barriers. Evidence and strategies to improve the assessment of human health risks due to environmental antibiotic resistance are also discussed.

Idioma originalEnglish
Páginas (de-até)637-652
Número de páginas16
RevistaEnvironmental Toxicology and Chemistry
Volume43
Número de emissão3
DOIs
Estado da publicaçãoPublicado - mar. 2024

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