@inproceedings{7107cf947d2742f6a85b731a093f8954,
title = "The importance of helicobacter pylori's genetic variability for the construction of an efficient vaccine",
abstract = "Helicobacter pylori is responsible for several gastric diseases. The main constraints of vaccine trials against this pathogen are mainly due to the bacterium high antigenic variability and to down-regulation of the host immune responses. To counteract these factors we propose a DNA vaccine able to induce a balanced humoural and citotoxic specific immune responses, based on multi-antigens. The selection of the antigens NapA, HpaA, VacA and HomB were conducted based on immunoproteomic data and the protein role on infection and pathogenesis. A fragment of each target-antigen was selected by in silico methods based on the maximization of the gene conservation and antigenicity. The set of these small fragments will be presented as a vaccine based on several conserved epitopes of multi-antigenic targets, and consequently representative of the bacterium antigenic variability.",
keywords = "Conserved epitopes, DNA vaccine, Genetic variability, Helicobacter pylori, Multi-antigeni",
author = "Filipa Vaz and Andreia Couto and Calado, \{Cecilia R. C.\}",
year = "2012",
doi = "10.1109/ENBENG.2012.6331369",
language = "English",
isbn = "9781467345248",
series = "2012 IEEE 2nd Portuguese Meeting in Bioengineering, ENBENG 2012",
booktitle = "2012 IEEE 2nd Portuguese Meeting in Bioengineering, ENBENG 2012",
note = "2012 IEEE 2nd Portuguese Meeting in Bioengineering, ENBENG 2012 ; Conference date: 23-02-2012 Through 25-02-2012",
}