The influence of aloe vera with mesenchymal stem cells from dental pulp on bone regeneration: characterization and treatment of non-critical defects of the tibia in rats

Isadora Mello Vilarinho Soares, Gustavo Vicentis de Oliveira Fernandes, Larissa Cordeiro Cavalcante, Yulla Klinger Pereira de Carvalho Leite, Dayseanny de Oliveira Bezerra, Maria Acelina Martins de Carvalho, Carmen Milena Rodrigues Siqueira Carvalho*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

12 Citações (Scopus)
1 Transferências (Pure)

Resumo

Objective: This study aimed to evaluate the inflammatory effect and bone formation in sterile surgical failures after implantation of a collagen sponge with mesenchymal stem cells from human dental pulp (hDPSCs) and Aloe vera. Material and Methods: Rattus norvegicus (n=75) were divided into five experimental groups according to treatment: G1) control (blood clot); G2) Hemospon®; G3) Hemospon® in a culture medium enriched with 8% Aloe vera; G4) Hemospon® in a culture medium containing hDPSCs and G5) Hemospon® in a culture medium enriched with 8% Aloe vera and hDPSCs. On days 7, 15 and 30, the animals were euthanized, and the tibia was dissected for histological, immunohistochemistry and immunofluorescence analyses. The results were analyzed using nonparametric Kruskal-Wallis test and Dunn’s post-test. Results: On days 7 and 15, the groups with Aloe vera had less average acute inflammatory infiltrate compared to the control group and the group with Hemospon® (p
Idioma originalEnglish
Número do artigoe20180103
RevistaJournal of Applied Oral Science
Volume27
DOIs
Estado da publicaçãoPublicado - 2019

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