The mammalian nonsense-mediated mRNA decay pathway: To decay or not to decay! Which players make the decision?

Ana Luísa Silva, Luísa Romão*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

116 Citações (Scopus)

Resumo

Nonsense-mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination codons (PTCs). Although the core process and several NMD effectors are conserved among species, the involvement of a splicing-dependent signal seems to be specific for mammalian PTC definition. Still, recent data shed new light on physical parameters and mechanistic pathways involved in NMD. Here, we examine these findings, updating the roles for potential NMD players, such as the exon junction complex and the cytoplasmic poly(A)-binding protein 1 - the former acting as enhancer rather than an essential factor and the latter functioning as NMD repressor.

Idioma originalEnglish
Páginas (de-até)499-505
Número de páginas7
RevistaFEBS Letters
Volume583
Número de emissão3
DOIs
Estado da publicaçãoPublicado - 4 fev. 2009
Publicado externamenteSim

Impressão digital

Mergulhe nos tópicos de investigação de “The mammalian nonsense-mediated mRNA decay pathway: To decay or not to decay! Which players make the decision?“. Em conjunto formam uma impressão digital única.

Citação