TY - JOUR
T1 - The mammalian nonsense-mediated mRNA decay pathway
T2 - To decay or not to decay! Which players make the decision?
AU - Silva, Ana Luísa
AU - Romão, Luísa
PY - 2009/2/4
Y1 - 2009/2/4
N2 - Nonsense-mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination codons (PTCs). Although the core process and several NMD effectors are conserved among species, the involvement of a splicing-dependent signal seems to be specific for mammalian PTC definition. Still, recent data shed new light on physical parameters and mechanistic pathways involved in NMD. Here, we examine these findings, updating the roles for potential NMD players, such as the exon junction complex and the cytoplasmic poly(A)-binding protein 1 - the former acting as enhancer rather than an essential factor and the latter functioning as NMD repressor.
AB - Nonsense-mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination codons (PTCs). Although the core process and several NMD effectors are conserved among species, the involvement of a splicing-dependent signal seems to be specific for mammalian PTC definition. Still, recent data shed new light on physical parameters and mechanistic pathways involved in NMD. Here, we examine these findings, updating the roles for potential NMD players, such as the exon junction complex and the cytoplasmic poly(A)-binding protein 1 - the former acting as enhancer rather than an essential factor and the latter functioning as NMD repressor.
KW - NMD factor
KW - Nonsense-mediated mRNA decay
KW - Poly(A)-binding protein
KW - Premature translation termination codon
KW - RNA-protein interaction
UR - http://www.scopus.com/inward/record.url?scp=58649117962&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2008.12.058
DO - 10.1016/j.febslet.2008.12.058
M3 - Short survey
C2 - 19162024
AN - SCOPUS:58649117962
SN - 0014-5793
VL - 583
SP - 499
EP - 505
JO - FEBS Letters
JF - FEBS Letters
IS - 3
ER -