The NAD interactome: identification of putative new NAD-binding proteins

Sara Duarte-Pereira*, Sérgio Matos, José Luís Oliveira, Raquel M. Silva

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

Resumo

Nicotinamide adenine dinucleotide (NAD) is an essential metabolite in normal cellular physiology and its deregulation may lead to several pathological conditions. NAD interacts with a vast number of proteins, acting as a coenzyme, as a substrate and regulating the interaction between proteins. The goals of this study were to characterize the proteins involved in NAD metabolism and to identify putative new NAD regulated proteins. Using an in silico approach, we first defined a NAD-binding dataset, that we characterized through pathway enrichment analysis and protein structural domains analysis. We then screened the full human proteome and further analyzed a selection of potential NAD-binding proteins. This global study of the NAD interactome resulted in the identification of new potentially NAD-binding proteins (NADPBs), including TRPC3 and a few isoforms of DGA kinases, which are involved in calcium signaling. NADBPs participate in several metabolic pathways and signaling processes in the cell, while proteins interacting with NADPBs are mostly involved in signaling pathways, including pathways related to disease, namely three major neurodegenerative diseases, Alzheimer’s, Huntington’s, and Parkinson’s.
Idioma originalEnglish
Título da publicação do anfitriãoPractical Applications of Computational Biology and Bioinformatics, 16th International Conference, PACBB 2022
EditoresFlorentino Fdez-Riverola, Miguel Rocha, Mohd Saberi Mohamad, Simona Caraiman, Ana Belén Gil-González
Local da publicaçãoCham
EditoraSpringer Nature Switzerland AG
Páginas43-54
Número de páginas12
Volume553
ISBN (eletrónico)9783031170249
ISBN (impresso)9783031170232
DOIs
Estado da publicaçãoPublicado - 2023
Evento16th International Conference on Practical Applications of Computational Biology & Bioinformatics - L'Aquila
Duração: 13 jul. 202215 jul. 2022
https://www.pacbb.net/

Série de publicação

NomeLecture Notes in Networks and Systems
Volume553
ISSN (impresso)2367-3370
ISSN (eletrónico)2367-3389

Conferência

Conferência16th International Conference on Practical Applications of Computational Biology & Bioinformatics
Título abreviadoPACBB'22
País/TerritórioItaly
CidadeL'Aquila
Período13/07/2215/07/22
Endereço da Internet

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